Finnish Atherosclerosis Society / Suomen Ateroskleroosiyhdistys ry Sixth Annual Meeting in Helsinki Time: 16.-17.3.2012 Place: Biomedicum, Haartmaninkatu 8, Helsinki
Friday 16.3. 12:30-13:15 Registration + Coffee Opening words Origins of metabolic complications in obesity: Adipose tissue inflammation and ectopic fat Kirsi Pietiläinen, Obesity Research Unit Helsinki University Central Hospital, Helsinki Session I Basic and translational research
Chairs: Kati Öörni and Vesa OlkkonenKnockout of Usf1 reduces atherosclerosis and leads to a favorable metabolic phenotype in mice Pirkka-Pekka Laurila, National Institute for Health and Welfare, Biomedicum, Helsinki Decreased cholesterol uptake to mouse peritoneal macrophages lacking Usf1 implies a leukocyte specific mechanism for the pro- atherogenic role of Usf1 Essi Kaiharju, National Institute for Health and Welfare, Biomedicum, Helsinki Acidic pH facilitates HDL interconversion into larger and lipid-poor apoA-I containing particles enhancing macrophage cholesterol efflux Su Nguyen, Wihuri Research Institute, Helsinki Nitro-oleic acid regulates endothelin receptor B expression in endothelial cells via transcription factor Nrf2 Emilia Kansanen, Department of Biotechnology and Molecular Medicine, A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio
15:30-15:45 Fatty acyl esterification and deesterification of 17β-estradiol in human subcutaneous adipose tissue Feng Wang, Folkhälsan Research Center, Institute of Clinical Medicine, University of Helsinki, and Division of Cardiology, Helsinki University Central HospitalOxysterol binding proteins in adipose tissue – Role in fat cell differentiation You Zhou, Minerva Foundation Institute for Medical Research, Helsinki Transcriptomal analysis of mouse adipose tissue suggests a role for USF1 in regulation of energy metabolism and inflammation Emmi Rautaheimo, National Institute for Health and Welfare, Helsinki University Certral Hospital, Biomedicum, Helsinki Hyperosmolarity induced lipid droplets formations relies on group VI phospholipases A2 activation and ceramide production Alexandra Robciuc, Helsinki Eye Lab, Department of Ophthalmology, National Institute for Health and Welfare, Biomedicum, Helsinki PPARδ/RXR inhibits lipoprotein lipase (LPL) activity and LPL- dependent fatty acid uptake via angiopoietin-like 4 in myotubes Marius Robciuc, National Institute for Health and Welfare, Biomedicum, Helsinki PNPLA3 is regulated by glucose via CHREBP and its I148M mutant slows down triglyceride hydrolysis in human hepatocytes Julia Perttilä, Minerva Foundation Institute for Medical Research, Helsinki Lipid bodies in human mast cells: distinct sites for eicosanoid biosynthesis Andrea Dichlberger, Wihuri Research Institute, Helsinki Suomen Ateroskleroosiyhdistys ry:n 6. sääntömääräinen vuosikokous Dinner in Biomedicum Saturday 17.3. Session II Genetic and clinical studies Chairs: Terhi Vihervaara and Matti Jauhiainen Ideal Cardiovascular Health in Childhood and Cardiometabolic Outcomes in Adulthood. The Cardiovascular Risk in Young Finns Study Markus Juonala, University Hospital and University of Turku Adolescence Risk Factors are Predictive of Coronary Artery Calcification at Middle Age. The Cardiovascular Risk in Young Finns Study Olli Hartiala, Research Centre of Applied and Preventive Cardiovascular Medicine, Turku Youth Adiposity and Metabolic Derangements in Predicting Intima- Media Thickness, Type 2 Diabetes and Cardiovascular Risk Factors in Adulthood. The Cardiovascular Risk in Young Finns Study Juha Koskinen, Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku Serum uric acid is not causally linked to carotid intima-media thickness. The Cardiovascular Risk in Young Finns Study. Mervi Oikonen, Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku Metabolic syndrome and mortality to cardiovascular diseases Merja Santaniemi, Institute of Clinical Medicine, University of Oulu and Oulu University Hospital Laboratory measurements of high-density lipoprotein cholesterol - problems and possible solutions Jaana Leiviskä, National Institute for Health and Welfare, Helsinki Sex differences in the relation between obesity and serum lipoprotein subclass profile: a twin study approach Leonie Bogl, Department of Public Health, University of Helsinki Liver fat accumulation predicts the risk of fatal cardiovascular endpoint Pauliina Pisto, Institute of Clinical Medicine, University of Oulu, Oulu University Hospital
Session III Immune system and inflammation in atherosclerosis Chairs: Pirkko Pussinen and Petri Kovanen The balance of serum matrix metalloproteinase-8 and its tissue inhibitor in acute coronary syndrome and its recurrence Erkki Pesonen, Children’s Hospital, University of Helsinki, Skåne University Hospital, Lund, Sweden Missing teeth associate with incident coronary heart disease events but not with diabetes Pirkko Pussinen, Institute of Dentistry, University of HelsinkiDental caries in childhood affects QT interval in adulthood. The Cardiovascular Risk in Young Finns Study Kari-Matti Mäkelä, Department of Clinical Chemistry, Tampere University Hospital and University of Tampere Bacterial signatures in thrombus aspirates of patients with myocardial infarction Tanja Pessi, School of Medicine, University of Tampere and Fimlab Laboratories Ltd, Pirkanmaa Hospital District, Tampere
Bacteria and Activity of Toll-Like Receptor - Dependent Signaling Pathways in Ruptured Fibrous Cap of Coronary Plaques Pekka Karhunen, Medical School, University of Tampere and Research Unit of the Fimlab Laboratories, Tampere
Immunization with Malondialdehyde Modified Low-Density Lipoprotein Reduces Atherosclerosis in LDLR-/- Mice Challenged with Periodontopathogen Porphyromonas gingivalis Pauliina Turunen, Department of Medical Microbiology and Immunology, Institute of Diagnostics, University of Oulu
Identification and characterization of human monoclonal Fab antibodies against MAA-LDL Chunguang Wang, Institute of Diagnostics, Department of Medical Microbiology and Immunology, University of Oulu
Acidic pH Triggers Secretion of Proinflammatory Cytokines in Human Macrophages Kristiina Rajamäki, Wihuri Research Institute, Helsinki Closing words Matti Jauhiainen Lunch and farewell
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