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An ISO 9001:2000 Certified Company 4-[4-Dimethyl amino)-1-(4’-fluoro phenyl)-1- Section 1 - Chemical Product and Company PRODUCT NAME: 4-[4-Dimethyl amino)-1-(4’- fluoro phenyl)-1-hydroxybutyl-3-(hydroxy 303, 3rd Floor, Royale Manor, Law Garden, Ellisbridge, Ahmedabad - 380006, Gujarat, India. Material Use: Intermediate for Escitalopram Section 2. Composition/information on ingredients Composition: 4-[4-Dimethyl amino)-1-(4’-fluoro phenyl)-1-hydroxybutyl-3-(hydroxy Section3. Hazards identification, including Appearance: white solid. Caution! May cause eye, skin, and respiratory tract irritation. The toxicological properties of this material have not been fully investigated. Target Organs: No data found. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. 303, 3rd Floor, Royale Manor, Law Garden, An ISO 9001:2000 Certified Company Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatical l General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Flash Point: Not applicable. Autoignition Temperature: Not applicable. Explosion Limits, Lower:Not available. Upper: Not available. NFPA Rating: (estimated) Health: 1; Flammability: 0; Instability: 0 General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep in tightly closed container. Store at 25°C excursion permitted to 15-35°C. Avoid exposure to excessively warm temperatures and moisture. 303, 3rd Floor, Royale Manor, Law Garden, An ISO 9001:2000 Certified Company Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne OSHA Vacated PELs: 4-[4-Dimethyl amino)-1-(4’-fluoro phenyl)-1-hydroxybutyl-3-(hydroxy methyl)-benzonitrile hydrobromide: No OSHA Vacated PELs are listed for this chemical. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9. Physical and chemical properties Physical State: Solid Appearance: A Pale yellow to an off-white colored powder Odor: odorless pH: Not available. Vapor Pressure: Not available. Vapor Density: Not available. Evaporation Rate:Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 198.0°C – 208.0°C Decomposition Temperature:Not available. Solubility: Soluble in methanol Specific Gravity/Density:Not available. Molecular weight : 423.32 Molecular Formula : C20H24BrFN2O2 303, 3rd Floor, Royale Manor, Law Garden, An ISO 9001:2000 Certified Company Chemical Stability: Stable at room temperature in closed containers under normal storage Incompatibilities with Other Materials: Strong oxidizing agents, excessive heat. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and Hazardous Polymerization: Has not been reported RTECS#: CAS# 103146-26-5 unlisted. LD50/LC50:Not available. Carcinogenicity:CAS# 103146-26-5: Not listed by ACGIH, IARC, NTP, or CA Prop 65. Effects of Acute Exposure: Data not available Effects of Chronic Exposure: Data not available Irritancy of Product: Data not available Skin Sensitization: Data not available Respiratory Sensitization: Data not available Carcinogenicity-IARC : Data not available Carcinogenicity – ACGIH: Data not available Reproductive Toxicity: Data not available Teratogenicity: Data not available Embryotoxicity: Data not available Mutagenicity: Data not available Name of Synergistic Products / Effects: Data not available Section 12. Ecological information No information is available about the potential of this product to produce adverse environmental affects. Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P-Series: None listed. RCRA U-Series: None listed. 303, 3rd Floor, Royale Manor, Law Garden, An ISO 9001:2000 Certified Company Special Shipping Information: It has no known significant hazards requiring special packaging or labeling for shipping purpose. US FEDERAL TSCA CAS# 103146-26-5 is not listed on the TSCA inventory. Health & Safety Reporting List None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules None of the chemicals in this product are under a Chemical Test Rule. Section 12b None of the chemicals are listed under TSCA Section 12b. TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. CERCLA Hazardous Substances and corresponding RQs None of the chemicals in this material have an RQ. SARA Section 302 Extremely Hazardous Substances None of the chemicals in this product have a TPQ. Section 313 No chemicals are reportable under Section 313. Clean Air Act: This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE CAS# 103146-26-5is not present on state lists from CA, PA, MN, MA, FL, or NJ. California Prop 65 California No Significant Risk Level: None of the chemicals in this product are listed. 303, 3rd Floor, Royale Manor, Law Garden, An ISO 9001:2000 Certified Company European Labeling in Accordance with EC Directives S 24/25 Avoid contact with skin and eyes. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). S 28A after contact with skin wash immediately with plenty of water CAS# 103146-26-5: No information available. Canada - DSL/NDSL CAS# 103146-26-5 is listed on Canada's NDSL List. Canada - WHMIS WHMIS: Not available. This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations. Canadian Ingredient Disclosure List Section 16. Other information The information above is believed to be accurate and represents the best information currently available to us. However, MANUS AKTTEVA make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall MANUS AKTTEVA be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages. 303, 3rd Floor, Royale Manor, Law Garden,

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