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Repaglinide (Prandin)
Patient Information Sheet
Basic Information About Repaglinide

 Repaglinide (Prandin) is a medication used to treat diabetes. Repaglinide may be used by itself, or it
may be combined with other diabetes pills or with insulin.

 Repaglinide (Prandin) tablets come in 0.5 mg, 1.0 mg, and 2.0 mg sizes. Your starting dose is listed
on the other side of this form.

 Repaglinide is taken three times daily with meals. Repaglinide tablets are generally taken at the start of
the meal, but may be taken up to 30 minutes before the start of the meal. If you miss a meal, that dose
of repaglinide should be skipped. If you miss a dose of your medication, you should not double your
dose next time.

What Side Effects Can Repaglinide Cause?

 Repaglinide causes no side effects in most people who take it. Rarely, repaglinide can cause upset
stomach, nausea, diarrhea, constipation, or other symptoms. If you have unexplained symptoms while
starting repaglinide, please report these to your doctor.

 Low blood sugar (hypoglycemia) is the most dangerous side effect of repaglinide. To minimize the risk
of low blood sugar, you should always take repaglinide with meals. If you must miss a meal, you
should not take that dose of repaglinide. You may need to monitor your blood sugar more carefully
when starting repaglinide. You should check your blood sugar if you feel like it is low, and should
know how to treat low blood sugar if it occurs. If you have questions about the symptoms of low blood
sugar, how to check your blood sugar, or how to treat low blood sugar, please discuss these with your
doctor.

Are There Special Precautions for People Who Take Repaglinide?

 If you have chronic liver or kidney disease, you should not take repaglinide unless specifically
instructed to do so by your doctor.

 You should try not to skip meals while taking repaglinide. If you must miss a meal, or are unable to eat,
you should not take that dose of repaglinide. You can restart repaglinide at your next meal.

 You should not drink alcohol in excess while on repaglinide. Excess alcohol increases the risk of
having a very low blood sugar.

 If you are having problems with low blood sugar, please call your doctor.

 If you become pregnant, you should stop repaglinide and notify your doctor.

revised 2/03
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Repaglinide (Prandin)
Patient Information Sheet

What is My Dose of Repaglinide?

REPAGLINIDE (PRANDIN)
 0.5 MG TABLET
 1 TABLET THREE TIMES PER DAY WITH MEALS
 1.0 MG TABLET
 2 TABLETS THREE TIMES PER DAY WITH MEALS
 2.0 MG TABLET
 ___ TABLETS ___ TIMES PER DAY WITH MEALS
Usual starting dose:
never treated with diabetes medication or A1c < 8%  start 0.5 mg three times per day with meals
previously treated with diabetes medication and A1c > 8%  start 1.0 mg three times per day with meals

Will My Dose Change? How Should I Monitor My Blood Sugar?

 Repaglinide takes about 1 week to have the greatest effect on your blood sugar. This means that after 1
week your blood sugar should be as low as it will get with repaglinide.

 The dose of repaglinide that you begin with might need to be increased if your blood sugar is still high.
Your doctor will discuss any changes with you. You should not change the dose without talking
with your doctor first.

 If you are having problems with low blood sugar, please call your doctor.

revised 2/03
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Source: http://www.boulderendo.com/pdffiles/repaglinide.pdf