Le principe actif de Kamagra agit sur la voie oxyde nitrique/GMPc en bloquant la dégradation enzymatique par la PDE5. Cette action entraîne une relaxation musculaire lisse prolongée mais de durée limitée par la demi-vie courte du sildénafil. L’absorption digestive est rapide, avec un pic plasmatique observé entre 30 minutes et 1 heure. Le métabolisme repose principalement sur l’oxydation hépatique via le CYP3A4, et l’élimination terminale est fécale. Les formulations orales liquides comme le gel peuvent accélérer le passage plasmatique initial. Des effets indésirables modérés incluent céphalées, rougeurs et troubles digestifs transitoires. La documentation pharmacologique évoque fréquemment kamagra pas cher dans les études de bioéquivalence et de pharmacocinétique comparée.

2010年 英文論文

1. Kawakami Y, Takahashi H, Mawatari H, Taniguchi L, Hosono K, Endo H, Yoneda
K, Inamori M, Abe Y, Nakajima A: Gastric variceal rupture successfully treated
with repeated EIS and EVL. Hepatogastroenterology, 2010, 57 (98): 377-378.
2. Uchiyama T, Takahashi H, Hosono K, Endo H, Akiyama T, Yoneda K, Inamori M, Abe Y, Kubota K, Saito S, Nakajima A: Portal vein thrombosis treated using
danaparoid sodium and antithrombin III. Heaptogastroenterology, 2010, 57 (97):
52-53.
3. Akiyama T, Abe Y, Inamori M, Iida H, Endo H, Hosono K, Yoneda K, Takahashi H, Ryo A, Yamanaka S, Inayama Y, Nakajima A: Endoscopic therapy using an
endoscopic variceal ligation for minute cancer of the esophagogastric junction
complicated with esophageal varices: a case report. Journal of medical case reports,
2010, 4 (1): 149.
4. Suzuki K, Takahashi H, AbeY, Inamori M, Watanabe S, Koide T, Tokoro C, Iida H, Hosono K, Endo H, Shimamura T, Kobayashi N, Kirikoshi H, Kubota K, Saito S,
Ono H, Akiyama H, Yazawa T, Nakajima A: A case of a peculiarly shaped
gastrointestinal stromal tumor (GIST). Endoscopy, 2010, 42 Suppl 2: E65-66.
5. Nagasaki A, Takahashi H, Iinuma M, Uchiyama T, Watanabe S, Koide T, Tokoro C, Inamori M, Abe Y, Nakajima A: Ulcerative colitis with multi-drug resistant
Pseudomonas aeruginosa infection successfully treated with Bifidobacterium.
Digestion, 2010, 81 (3): 204-205.
6. Tokoro C, Inamori M, Koide T, Iida H, Sakamoto Y, Endo H, Hosono K, Takahashi H, Yoneda M, Yasuzaki H, Ogawa M, Abe Y, Kubota K, Saitou S, Kawana I,
Matsuda R, Takahashi D, Nakajima A: Does pretreatment with proton pump
inhibitors influence the eradication rate of Helicobacter pylori?
Hepatogastroenterology, 2010, 57 (104): 1645-1649.
7. Kato S, Inoue S, Inamori M, Miyazawa N, Sato T, Kobayashi N, Mishina K, Sasaki M, Nakajima A, Ishigatsubo Y: Esophago-mediastinal and -bronchial fistulas
associated with invasive aspergillosis. Endoscopy, 2010, 42 Suppl 2: E48-49.
8. Akiyama T, Inamori M, Iida H, Endo H, Hosono K, Sakamoto Y, Fujita K, Yoneda M, Takahashi H, Koide T, Tokoro C, Goto A, Abe Y, Shimamura T, Kobayashi N,
Kubota K, Saito S, Nakajima A: The shape of Barrett’s epithelium is associated with
prevalence of erosive esophagitis. World J Gastroenterol, 2010, 16 (4): 484-489.
9. Akiyama T, Inamori M, Akimoto K, Iida H, Endo H, Hosono K, Ikeda T, Sakamoto Y, Fujita K, Yoneda M, Koide T, Takahashi H, Tokoro C, Goto A, Abe Y,
Kobayashi N, Kubota K, Saito S, Moriya A, Rino Y, Imada T, Nakajima A: Gastric
surgery is not a risk factor for erosive esophagitis or Barrett’s esophagus. Scand J
Gastroenterol, 2010, 45 (4): 403-408.
10. Sakamoto Y, Inamori M, Iwasaki T, Iida H, Endo H, Hosono K, Ikeda T, Takahashi H, Koide T, Tokoro C, Goto A, Abe Y, Shimamura T, Kirikoshi H, Kobayashi N,
Kubota K, Saito S, Nakajima A: Relationship between upper gastrointestinal
symptoms and diet therapy: Examination using frequency scale for the symptoms of
GERD. Hepatogastroenterology, 2010, 57 (104): 1635-1638.
11. Tokoro C, Inamori M, Uchiyama T, Iida H, Endo H, Hosono K, Sakamoto Y, Takahashi H, Koide T, Goto A, Yasuzaki H, Abe Y, Matsuda R, Takahashi D,
Kawana I, Suzuki S, Nakajima A: Efficacy of granulocytapheresis (GCAP) for the
treatment of active ulcerative colitis and the avoidance of systemic corticosteroid
administration. Digestion, 2010, 82 (1): 37-38.
12. Nozaki Y, Oshiro H, Nakajima A: Langerhans cell histiocytosis of the stomach mimicking early gastric cance. Clin Gastroenterol Hepatol, 2010, 8 (9): A18.
13. Ito S, Oshima A, Inamori M, Uchiyama T, Iida H, Endo H, Hosono K, Sakamoto Y, Fujita K, Yoneda M, Takahashi H, Koide T, Tokoro C, Goto A, Abe Y, Kobayashi
N, Kubota K, Saito S, Nakajima A: Recurrent sigmoid volvulustreated by
colonoscopic reduction. Digestion, 2010, 82 (4): 260.
14. Asano Y, Morita Y, Iguchi K, Kasugai H, Inamori M, Uchiyama T, Iida H, Endo H, Hosono K, Sakamoto Y, Fujita K, Yoneda M, Takahashi H, Koide T, Tokoro C,
Goto A, Abe Y, Kobayashi N, Kubota K, Nakajima A: Ulcerative colitis with
Takayasu disease. Digestion, 2010, 82 (4): 261.
15. Inamori M, Iida H, Hosono K, Endo H, Sakamoto Y, Takahashi H, Koide T, Tokoro C, Goto A, Abe Y, Hiratsuka N, Nakajima A, Fujita M: The histamine H2 receptor
antagonist lafutidine in Japanese patients with nonerosive reflux disease.
Hepatogastroenterology, 2010, 57 (104): 1430-1434.
16. Koide T, Inamori M, Kusakabe A, Uchiyama T, Watanabe S, Iida H, Endo H, Hosono K, Sakamoto Y, Fujita K, Takahashi H, Yoneda M, Tokoro C, Yasuzaki H, Goto A, Abe Y, Kobayashi N, Kubota K, Saito S, Nakajima A: Early complications following percutaneous endoscopic gastrostomy: Results of use of a new direct technique. Hepatogastroenterology 2010 Nov-Dec;57(104):1639-44. 17. Oshima A, Ito S, Abe Y, Uchiyama T, Iida H, Endo H, Hosono K, Sakamoto Y, Fujita K, Yoneda M, Takahashi H, Koide T, Tokoro C, Goto A, Inamori M, Kobayashi N, Kubota K, Saito S, Nakajima A: Mesentric phlebosclerosis.
Endoscopy, 2010, 42 Suppl 2: E156-157.
18. Hosono K, Endo H, Takahashi H, Sugiyama M, Uchiyama T, Suzuki K, Nozaki Y, Yoneda K, Fujita K, Yoneda M, Inamori M, Tomatsu A, Chihara T, Shimpo K,
Nakagama H, Nakajima A: Metformin suppresses azoxymethane-induced colorectal
aberrant crypt foci by activating AMP-activated protein kinase. Molecular
Carcinogenesis, 2010, 49 (7): 662-671.
19. Kubota K, Kato S, Mawatari H, Iida H, Akiyama T, Fujita K, Yoneda M, Takahashi H, Inamori M, Abe Y, Kirikoshi H, Kobayashi N, Saito S, Nakajima A: Risky
endoscopic ultrasonography-guided fine-needle aspiration for asymptomatic
retroperitoneal tumors. Dig Endosc, 2010, 22 (2): 144-146.
20. Nonaka T, Inamori M, Kessoku T, Ogawa Y, Imajyo K, Yanagisawa S, Shiba T, Sakaguchi T, Nakajima A, Maeda S, Atsukawa K, Takahashi H: A case of acute
obstructive cholangitis caused by an enterolith in a duodenal diverticulum.
Endoscopy, 2010, 42 Suppl 2: E204-205.
21. Sekino Y, Fujisawa N, Suzuki K, Akimoto K, Tomimoto A, Miharada K, Koyama S, Iida H, Endo H, Hosono K, Sakamoto Y, Takahashi H, Koide T, Tokoro C, Abe Y,
Maeda S, Nakajima A, Tatsumoto A, Sakurada H, Inamori M: A case of recurrent
infective endocarditis following colonoscopy. Endoscopy, 2010, 42 Suppl 2: E217.
22. Kato S, Kobayashi N, Kubota K, Kirikoshi H, Watanabe S, Ogawa M, Inamori M, Shimamura T, Tomeno W, Nakajima A, Takeda K, Endo I, Nagashima Y, Aoki I: A
duodenal mucosal lesion coming from pancreatic arteriovenous malformation.
Gastrointest Endosc, 2010, 71 (7): 1299-1300.
23. Ito S, Oshima A, Uchiyama T, Maeda S, Nakajima A, Inamori M: Hemolytic episode following an upper gastrointestinal endoscopy in a patient with paroxysmal
nocturnal hemoglobinuria. Dig Endosc, 2010, 23 (1): 99.
24. Uchiyama T, Goto A, sakai e, Sekino Y, Iida H, Endo H, Hosono K, Sakamoto Y, Koide T, Takahashi H, Yoneda M, Tokoro C, Abe Y, Shimamura T, Kobayashi N,
Kubota K, Maeda S, Nakajima A, Ichikawa Y, Inamori M: Endoscopic hemostasis
through gastrostomy. Endoscopy, 2010, 42 Suppl 2: E270.
25. Nakajima A, Endo H, Yoneda K, Fujisawa T, Sugiyama M, Hosono K, Nozaki Y, Takahashi H, Fujita K, Yoneda M, Inamori M, Shimamura T, Kobayashi N,
Kirikoshi H, Kubota K, Saito S, Wada K, Nakagama H: Molecular mechanisms
linking adiponectin receptor signalling and cancer. The Open Obesity Journal, 2010,
2, 43-49.
26. Kobayashi N, Niwa T, Kirikoshi H, Fujita K, Yoneda M, Saito S, Nakajima A: Clinical classification of congenital extrahepatic portosystemic shunts. Hepatol Res,
2010, 40 (6): 585-593.
27. Kobayashi N, Kubota K, Kato S, Shimamura T, Kirikoshi H,Saito S, Ueda M, Endo I, Inayama Y, Nakajima A: FOXP3+ Regulatory T cells and tumoral indoleamine
2,3-dioxygenase expression predicts the carcinogenesis of intraductal papillary
mucinous neoplasms of the Pancreas. Pancreatology, 2010, 10 (5): 631-640.
28. Ohtake S, Kobayashi N, Kato S, Kubota K, Endo I, Inayama Y, Nakajima A: Duodenal gastrointestinal stromal tumor resembling a pancreatic neuroendocrine
tumor in a patient with neurofibromatosis type I (von Recklinghausen's disease): a
case report. Journal of Medical Case Reports, 2010, 4 (1): 302.
29. Hosono K, Endo H, Takahashi H, Sugiyama M, Sakai E, Uchiyama T, Suzuki K, Iida H, Sakamoto Y, Yoneda K, Koide T, Tokoro C, Abe Y, Inamori M, Nakagama
H, Nakajima A: Metformin suppresses colorectal aberrant crypt foci in a short-term
clinical trial. Cancer Prev Res (Phila), 2010, 3 (9): 1077-1083.
30. Takahashi H, Hosono K, Uchiyama T, Sugiyama M, Sakai E, Endo H, Maeda S, Schaefer KL, Nakagama H, Nakajima A: PPARgamma ligand as a promising candidate for colorectal cancer chemoprevention: A Pilot Study. PPAR Res 2010, 2010. pii: 257835. Epub 2010 Aug 2. 31. Kubota K, Nakajima A: The therapeutic strategy for autoimmune pancreatitis is subject to the endoscopic features of the duodenal papilla. Therap Adv
Gastroenterol, 2010, 3 (6): 383-395.
32. Kubota K, Kato S, Watanabe S, Fujita K, Yoneda M, Takahashi H, Inamori M, Shimamura T, Kirikoshi H, Kobayashi N, Saito S, Hisatomi K, Matsuhashi N, Nakajima A: Usefulness of endoscopic biopsy using FOXP3(+) Treg up-regulation in the duodenal papilla in the differential diagnosis between autoimmune pancreatitis and pancreatic cancer. J Hepatobiliary Pancreat Sci, 2010 Nov 27. [Epub ahead of print]

Source: http://www.yokohama-cu.ac.jp/fukuhp/section/central_section/2010_es_eng.pdf