Petr A. Kisselev
vil.Latygovo, Sennenski distr., Witebsk region, USSR
Chemical Faculty of the Byelorussian State University.
Chemical Faculty of the M.Luether – University (Halle-Wittenberg, DDR)
Post-graduate studentship at the Institute of Bioorganic Chemistry of the Byelorussian Academy of Sciences
Junior Research Assistant at the Institute of Bioorganic Chemistry of the Byelorussian Academy of Sciences
Senior Research Assistant at the Institute of Bioorganic Chemistry of the Byelorussian Academy of Sciences
Chief Research Labor at the Institute of Bioorganic Chemistry National Academy of Sciences of Belarus
Postdoctoral Research Associate at the Central Institute of
Molecular Biology German Academy of Sciences, Berlin-Buch (Prof. K.Ruckpaul)
Academic degree Senior Research Assistant
Stipendium of Finland Research Society at the Medical Faculty University of Kuopio (Finland). Superviser Prof. O. Haenninen
Stipendium of German Research Society at the M. Planck -
Institute of Biophysical Chemistry (Germany, Goettingen). Superviser Prof. A. Stier
Professor of Biochemistry and Biophysics Chair at the International Sakharov Environmental University
Academic degree Professor in Chemistry (Full Professor)
Stipendium of German Research Society at the Institute of
Clinical Pharmacology, Charite-Campus Mitte Humboldt
2000;2001;2002;2003; University of Berlin and Max Delbrueck Center for Molecular 2004;2005;2006;2007 Medicine (Germany,Berlin, Superviser Prof. I.Roots)
250 Scientific Publications, 4 Training Aids, 5 Invention Certificates of USSR and 1 Patent.
1. Schwarz D., Kisselev P., Schunck W.H., Roots I. Inhibition of 17β-estradiol
activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols // Biochim. Biophys. Acta. 2011 Jan;1814(1):168-174.
2. Schwarz D., Kisselev P., Chernogolov A., Schunck W.H., Roots I. Human CYP1A1
variants lead to differential eicosapentaenoic acid metabolite patterns // Biochem. Biophys. Res. Commun. 2005 Oct 28;336(3):779-783.
3. Kisselev P., Schunck W.H., Roots I., Schwarz D. Association of CYP1A1
polymorphisms with differential metabolic activation of 17beta-estradiol and estrone // Cancer Res. 2005 Apr 1;65(7):2972-2978.
4. Schwarz D., Kisselev P., Roots I. CYP1A1 genotype-selective inhibition of
benzo[a]pyrene activation by quercetin // Eur. J. Cancer. 2005 Jan;41(1):151-158.
5. Schwarz D., Kisselev P., Ericksen S.S., Szklarz G.D., Chernogolov A., Honeck H.,
Schunck W.H., Roots I. Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R),18(S)-epoxyeicosatetraenoic acid // Biochem. Pharmacol. 2004 Apr 15;67(8):1445-1457.
6. Schwarz D., Kisselev P., Roots I. St. John's wort extracts and some of their
constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 // Cancer Res. 2003 Nov 15;63(22):8062-8068.
7. Kisselev P., Schwarz D., Platt K.L., Schunck W.H., Roots I. Epoxidation of
benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 in reconstituted membranes. Effects of charge and nonbilayer phase propensity of the membrane // Eur. J. Biochem. 2002 Apr;269(7):1799-1805.
8. Schwarz D., Kisselev P., Honeck H., Cascorbi I., Schunck W.H., Roots I. Co-
expression of human cytochrome P4501A1 (CYP1A1) variants and human NADPH-cytochrome P450 reductase in the baculovirus/insect cell system // Xenobiotica. 2001 Jun;31(6):345-356.
9. Parul D.A., Bokut S.B., Kisselev P.A., Milyutin A.A., Petrov E.P., Nemkovich N.A.,
Sobchuk A.N., Dzhagarov B.M. Fluorescence decay time distribution analysis reveals two types of binding sites for 1,8-anilinonaphthalene sulfonate in native human oxyhemoglobin // Biochemistry (Mosc). 2001 Apr;66(4):390-396.
10. Schwarz D., Kisselev P., Cascorbi I., Schunck W.H., Roots I. Differential
metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 variants // Carcinogenesis. 2001 Mar;22(3):453-459.
11. Schwarz D., Kisselev P., Schunck W.H., Chernogolov A., Boidol W., Cascorbi I.,
Roots I. Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity // Pharmacogenetics. 2000 Aug;10(6):519-530.
12. Schwarz D., Chernogolov A., Kisselev P.Complex formation in vesicle-reconstituted
mitochondrial cytochrome P450 systems (CYP11A1 and CYP11B1) as evidenced by rotational diffusion experiments using EPR and ST-EPR // Biochemistry. 1999 Jul 20;38(29):9456-9464.
13. Kisselev P., Tuckey R.C., Woods S.T., Triantopoulos T., Schwarz D. Enzymatic
properties of vesicle-reconstituted human cytochrome P450SCC (CYP11A1) differences in functioning of the mitochondrial electron-transfer chain using human and bovine adrenodoxin and activation by cardiolipin // Eur. J. Biochem. 1999 Mar;260(3):768-773.
14. Kisselev P., Wessel R., Pisch S., Bornscheuer U., Schmid R.D., Schwarz D.
Branched phosphatidylcholines stimulate activity of cytochrome P450SCC (CYP11A1) in phospholipid vesicles by enhancing cholesterol binding, membrane incorporation, and protein exchange// J. Biol. Chem. 1998 Jan 16;273(3):1380-1386.
15. Schwarz D., Kisselev P., Pfeil W., Pisch S., Bornscheuer U., Schmid R.D. Evidence
that nonbilayer phase propensity of the membrane is important for the side chain cleavage activity of cytochrome P450SCC // Biochemistry. 1997 Nov 18;36(46):14262-14270.
16. Schwarz D., Kisselev P., Wessel R., Pisch S., Bornscheuer U., Schmid R.D.
Possible involvement of nonbilayer lipids in the stimulation of the activity of cytochrome P450SCC (CYP11A1) and its propensity to induce vesicle aggregation // Chem. Phys. Lipids. 1997 Feb 28;85(2):91-99.
17. Schwarz D., Kisselev P., Wessel R., Jueptner O., Schmid R.D. Alpha-branched 1,2-
diacyl phosphatidylcholines as effectors of activity of cytochrome P450SCC (CYP11A1). Modeling the structure of the fatty acyl chain region of cardiolipin // J. Biol. Chem. 1996 May 31;271(22):12840-12846.
18. Kisselev P.A., Smettan G., Kissel M.A., Elbe B., Zirwer D., Gast K., Ruckpaul K.,
Akhrem A.A. Reconstitution of the liver microsomal monooxygenase system in liposomes from dimyristoylphosphatidylcholine // Biomed. Biochim. Acta. 1984;43(3):281-293.
19. Akhrem A.A., Andrianov V.T., Bokut S.B., Luka Z.A., Kissel M.A., Skornyakova
T.G., Kisselev P.A.Thermotropic behaviour of phospholipid vesicles reconstituted with rat liver microsomal cytochrome P-450 // Biochim. Biophys. Acta. 1982 Nov 8;692(2):287-95.
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