Are antidepressant addictive? Steven felt he was living proof that Paxil was addicting. “I’m hooked on Paxil! I am a
Steven had stopped 20 mg per day of Paxil a few days
Yes, antidepressants such as Paxil can create both
ago. Just a few months earlier, he had stopped smoking
dependence and addiction. Patients such as Steven can
cigarettes cold turkey, after having been a 1-to-2-pack-a-
become dependent, where stopping the drug abruptly
day smoker for 19 years. Given his willpower in the face of
causes a debilitating withdrawal reaction. And they can
nicotine withdrawal, Steven assumed that he would have
become addicted, developing a tolerance to
no trouble going off Paxil even if he did experience
antidepressants and the need for higher and higher doses
withdrawal. He was wrong! He experienced debilitating
for effectiveness. As they have become less expensive
dizziness and headaches and felt “trapped” on his living
with the expiration of patents, antidepressant abuse has
room couch, unable to get up and even walk around the
become more common among high school and college
room. He also experienced severe aches and pains in his
students. In the New York magazine cover article
muscles and joints. He was totally drained of energy. His
“Generation Rx: Pop, Snort, Parachute,” the author
doctor had warned Steven about withdrawal and had
interviewed more than 50 teenagers, many of whom stole
suggested tapering. Steven did not believe how bad it
the antidepressants they were abusing from their parents’
could get, and how desperate he could get for a drug.
medicine cabinets. The “pills are more addictive than
Are Antidepressants Addictive or Habit Forming?
Antidepressant sales amounted to $13.5 billion last year
Over the past decade, pharmaceutical companies and
compared to $8.9 billion spent on psychotherapies. And
psychiatrists who are strong drug proponents have
that Rx figure excludes the accompanying medication
adamantly denied that antidepressants are addicting or
management and office visit charges of the MDs. How
habit forming. As antidepressant withdrawal began to
much of this spending is a result of patient addiction? How
come to the attention of doctors and patients in the mid-
well informed are new patients about the potential for
1990s, Eli Lilly, the manufacturer of Prozac, paid for a
antidepressant withdrawal and dependence? How much
group of psychiatric experts to meet and discuss the
influence have the pharmaceutical companies had on the
growing concern about this side effect. One of the main
prescribing patterns of antidepressants and the knowledge
outcomes of that meeting was the decision that the term
base, or lack thereof, among antidepressant users? With
“withdrawal” should not be used for antidepressants.
this class of drugs, there is great opportunity for improved
Instead, the group proposed that “antidepressant
training of physicians and education of patients, leading to
discontinuation syndrome” replace “withdrawal” to avoid
healthier outcomes and reduced spending than what we
the association with addiction. This kind of industry
are experiencing among our insured populations today.
behavior contributes to the challenges of getting honest,
Proactive programs can be designed to identify these
reliable information about antidepressant withdrawal,
opportunities and achieve these outcomes. Next month,
dependence and addiction in the hands of patients and
we will address what health plans can do to address this
An advertisement used to run on television which presented the wonderful benefits of Paxil treatment and concluded with a statement that “Paxil is not habit-forming.” Steven felt he was living proof that Paxil was addicting. “I’m hooked on Paxil! I am a Paxil junkie!” Could he really be addicted to Paxil?
The Behavioral Health Advisor is a monthly publication by Steve Melek, designed to
Stephen P. Melek, F.S.A., MAAA
bring interesting and informative behavioral health topics to the forefront. Melek is a
leading professional in combining actuarial expertise with behavioral health knowledge.
He consults on effective integration of medical and behavioral healthcare, efficiency in
delivery and successful health outcomes, predictive modeling, and collaborative
research with other disciplines. June 2007 milliman.com
Prolonged Methylprednisolone Treatment Suppresses Systemic Inflammation in Patients with Unresolving Acute Respiratory Distress Syndrome Evidence for Inadequate Endogenous Glucocorticoid Secretion and Inflammation-induced Immune Cell Resistance to Glucocorticoids G. Umberto Meduri, Elizabeth A. Tolley, George P. Chrousos, and Frankie Stentz Memphis Lung Resea
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