Meb.marshall.edu

BASIC SCIENCE DEPARTMENT

Biochemistry & Microbiology
a) Regulation and role of manganese superoxide dismutase b) Regulation and role of the putative tumor suppressor AP-2γ c) Regulation and role of Akt -The interaction of group B streptococcus with -Post-doctoral fellowship for Gabriela Ion Attenuation of preadipocytes/breast cancer cells communication with role in cancer prevention -Walnut consumption for benefit against prostate and breast cancer -Omega-3 fat to reduce risk for breast cancer 1R01CA114018-01A2 -Inhibition of nuclear factor kappa B in indolent B cell malignancies -West Virginia IdeA Networks of Biomedical -Genetic Basis of Methadone Overdose Susceptibility -Ultrasound guided gene delivery in pancreatic -Ultrasound guided site-specific gene delivery in prostate cancer -Expansion of stem doctoral education at Marshall -Developing a genetic system to evaluate the radiation effect on DNA damage and repair water pollutants -Genetic analysis of radiation effect on DNA repair mechanisms in P. Aeruginosa -Apoptosis & disease progression in a mouse model for polycystic kidney disease Pharmacology, Physiology & Toxicology -Genetics of diet-induce obesity in a new mouse -Diet-Wnt signaling interactions in a novel congenic mouse model of obesity -EGCG regulation of drug efflux transporters -Ecstasy metabolite transport into the brain -Oxidized lipids in cardiovascular disease -Obesity related biomarkers in patients with coronary artery disease in the appalachian region -Again, epicardial fat and cardio-metabolic risk -Nicotine, microRNAs and atherosclerosis -Obesity associated hypertension: Role of 12-lipoxygenase and perivascular fat -Effects of resveratrol on cisplatin nephrotoxicity -Mechanism of radiocontrast media renal toxicity -Nicotine/Acetylcholine signaling in lunch cancer -Nicotine receptor signaling in non-small cell lung -Nicotine receptor antagonists in therapy of lung cancers -Nicotine receptor signaling in atherogenesis -Nicotine receptor signaling in retinal angiogenesis -Anti-neoplastic activity of capsaicin in human small cell lung cancer -Growth hormone mechanisms in the regulation of -Mechanisms underlying effects of SNRI’s on synaptic plasticity and plasticity related molecules
CLINICAL DEPARTMENTS
-Randomized evaluation of long term anticoagulant therapy comparing the efficacy and safety of two blinded doses of dabigatran etexilate with open label warfarin for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: prospective, multi-centre, parallel-group, non-inferiority trial -RELY-ABLE: long term multi-center extension of dabigatran treatment in patients with atrial fibrillation who completed the RE-LY trial and a cluster randomized trail to assess the effect of a knowledge translation intervention on patient outcomes -Treatment of preserved cardiac function heart - A randomized, double blind, parallel-group study of cardiovascular safety in osteoarthritis or rheumatoid arthritis patients with or at high risk for cardiovascular disease comparing celecoxib with naproxen and ibuprofen -A prospective evaluation in a randomized trial of the safety and efficacy of the use of the TAXUS element paclitaxel-eluting coronary stent system for the treatment of De Novo Coronary Artery Lesions -A prospective evaluation in a non-randomized trial of the safety and efficacy of the use of the TAXUS element paclitaxel-eluting coronary stent system for the treatment of De Novo Coronary Artery Lestions in small vessels -A comparison of prasurgrel and clopidogrel in acute coronary syndrome (ACS)subjects with unstable angina/non-st-elevation myocardial infarction (UA/NSTEMI) who are medically managed -XIENCE V Everolimus eluting coronary stent system (EECSS) USA post-approval study -Perspectives of family medicine residents on residency curriculum regarding worldview thinking
Maurice Mufson, MD
-An open, randomized, multicenter study of the safety, tolerability, and immunogenicity of VAQTATM given concomitantly with PedvaxHIBTM and InfanrixTM in Healthy Children 15 months of age -An expanded phase 1/2A randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, immunogenicity, and viral shedding of MEDI-560, a live, attenuated recombinant parainfluenza virus type 3 (PIV#) vaccine, administered intranasally to healthy infants 1 to <12 months of age -A phase II randomized, observer blind, multicenter study of GlaxoSmithKline Biologicals’ combined measles-mumps-rubella-varicella vaccine (MMRV) versus Proquad®, according to a one does schedule, both administered sub-cutaneously at 12-14 months of age, concomitantly with Hepatitis A vaccine (HAV) and Pneumococcal Conjugate Vaccine (PCV) but at separate sites. -A phase 1/2A randomized, double-blind, placebo-controlled, dose-escalation study to evaluate the safety, tolerability, immunogenicity and vaccine-like viral shedding of MEDI-534, a live, attenuated intranasal vaccine against respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3), in healthy infants 6 to <24 month old children and in 2 month old infants -A phase II, randomized, observer blind, controlled, multicenter study to assess immunogenicity and antibody persistence following vaccination with GlaxoSmithKline’s Candidate combined measles, mumps, and rubella vaccine (MMR) versus M-M-R®II as a first-dose, both administered sub-cutaneously at 12-15 months of age, concomitantly with Hepatitis A vaccine (HAV), Varicella Vaccine (VV) and pneumococcal conjugate vaccine (PCV) but at separate sites -Efficacy Evaluation of Pneumococcal Vaccine -Data mining of the IDX database in Medicine for studies on vaccines mainly influenza vaccine and pneumococcus vaccine -Sulfapyridine supplies for clinic patient -Analysis and molecular epidemiology of common and resistant human pathogens in a micropolis -Who is colonized with MRSA in relation to a source patient -Who is colonized with MRSA in an incarcerated population -The effect of energy exercise on CD4 lymphocyte counts, HIV viral loads and perception of well being in an HIV/AIDS population -Prospective observational study on predictors of early on treatment response and sustained virological response in a cohort of treatment naïve HCV-infected patients treated with pegylated interferons -An international, multicenter, prospective, observational study of the safety of maraviroc used with optimized background therapy in treatment experienced HIV-1 infected patients -Effects of various types of trauma on peripheral -Properties of clinical electrodes with continuous and intermittent stimulation -Information content in constrained signals -Ultrasonic removal of intervertebral disc -Safety of ultrasonic surgery in relation to proximity -Mechanisms of pain relief in the treatment of lower limb chronic pain in patients with PVD -Anatomy of the lumbar intervertebral disc in relation to surgical insertion of prosthetic devices Department of Obstetrics & Gynecology -Outcomes of fetuses with absent or reversed end diastolic velocity in the umbilical artery using -The effect on neonatal outcomes of managing maternal hypertension using maternal cardiac dynamics to guide antihypertensive therapy -Prevalence of drug use in pregnant West Virginia patients -Routine follow up of ultrasound performed at Cabell Huntington Hospital Perinatal Center -Review of stillbirths (>20 wks gestation) to determine cause and if evaluation complies with -Prospective study to determine degree of urethral impringment that occurs with uteral sacral rixation by MRI measurement pre and post operatively -A retrospective review of term labor patients to determine the compliance with CDC guidelines for intrapartum group B streptococci prophylaxsis -A retrospective review of group B streptococci prophylaxsis in preterm pregnancy -Study the use of computer modules to teach -Randomized clinical trial to investigate the efficacy of mannitol in improving leg perfusion pressure in -Acanthosis nigricans as a clinical marker for insulin resistant diabetes mellitus in obese children -Season distribution of eosinophilic esophagitis (EoE) in children from West Virginia -Familial clustering of habitual constipation: A prospective study in children from West Virginia -Helicobacter pylori diagnostic tests in children: a review of the literature from 1999 to 2009 -Fluticasone reversed sub-epithelial fibrosis in children with eosinophilic esophagitis -A randomized, double-blind, parallel-group study to assess the safety and efficacy of Asacol® (1.2 to 4.8 g/day) administered as 400 mg delayed-release tablets given every 12 hours for 6 weeks to children and adolescents with mildly to moderately active ulcerative colitis -A randomized, double-blind, parallel-group study to assess the safety and efficacy of Asacol® (1.2 to 4.8 g/day) 400 mg delayed-release tablets given twice daily for 26 weeks to children and adolescents for the maintenance of remission of ulcerative colitis -Constipation – ADHD – and tic study (CATS) association of constipation, ADHD and tics (CATS) and the therapeutic effectiveness of stimulants on improving encopresis -The use of CBC and CRP for evaluating sepsis in -Respiratory outcomes using NCPAP vs. CPAP in premature infants >1500 g -Catheter associated bloodstream infections in the -Shaken baby syndrome in WV-Occurrence, morbidity, mortality and cost -Kidnitiative West Virginia and Healthykids -The rates of MRSA colonization among members -Pulmonary embolism presenting with sudden respiratory failure in two previously stable neonates -A decrease in retinopahy of prematurely (ROP) in extreme preterm infants managed with continuous positive airway pressure -Unusual left atrial appendage thrombosis in a neonate with poor ventricular contractibility Documenting the NICU design dilemma: parent and staff perceptions of open ward versus single family -Improved medical outcomes in neonatal intensive care signle family room units compared to open wards -Genetic analysis of radiation effect on DNA repair -WV water quality: fecal source tracking and pathogen profiling -Novel biopolymers for space exploration -Developing a genetic system to evaluate the radiation effect on DNA damage & repair -Retrospective chart review: The McDowell County -Case review on the effects of using avastin in trabeculectomy patients

Source: http://meb.marshall.edu/research/student-research/documents/Ongoing%20Research.pdf