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515 Diurectic
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Aldactone
12. How does CAI
brain know CO2 are high; thus signal more mountain
sickness?
13. How does
hypokalemia
for signaling insulin release, thus increase hyperglycemia?
14. How does K-
diuretics
mechanism
congestive heart failure, cirrhosis, renal 15. How does loop
diurectic cause
important for signaling, so loop diurectic ototoxicity in
can end up damaging ear at high dose.
high dose?
than other drugs, but it is not sulfonamide.
congestive heart failure, cirrhosis, renal 16. How does loop
diuretics cause
cause a lower positive charge on lumen side secretion of
thus attracting Ca and Mg to go into lumen and Mg to flow with them, blocking themwill decrease the absorption of Ca and Mg.
17. How does Loop
Diuretics
mechanism
Dyrenium
18. How does
using inert substance that will be filtered in diuretics
mechanism
19. How does
potassium help
congestive heart failure, cirrhosis, renal hypokalemia of
thizide and
reabsorbed which end up pulling potassium How does CAI
help with
loop diuretics
glacoma?
bicarbonate can decrease production of the 20. How does
Inhibit Na/Cl co-transport system in early Thiazide
distal tubule, enhance reabsorption of Ca, diuretics
mechanism
10. How does CAI
mechanism
21. How does
tolvaptan get
surrounding cell, cell will then secrete ions hyponatremia
11. How does CAI
CAI induce metabolic acidosis, which help anticonvulsant?
osmotic
demyelination
syndrome
22. How does
35. Trusopt
vasopressin receptor
antagonists (ADH
antagonist)
36. Two types of
mechanism works?
glaucoma?
23. Hydrodiuril
37. Vaprisol
24. Inspra
38. What cause angle
closure glaucoma
used alongside other diuretics toprevent/counteract hypokalemia 39. What cause open
angle glaucoma
25. Lasix
40. What does it mean
when there are high
plasma protein
41. What drug interferes
with loop diuretics?
26. Lozol
42. What drug lower
total peripheral
resistance long term?
27. Microzide
43. What is ADME of
acetazolamide and
methazolamide
high CA enzyme, diuresis 12 hrs,half life 10-15 hrs 28. Midamor
44. What is ADME of
ADH antagonist?
29. Neptazane
30. Osmitrol
intracranial (brain) or intraocular(eye) pressure 45. What is ADME of
Amiloride and
31. Samsca
Triamterene
32. Sequels
33. Thalitone
46. What is ADME of
Brinzolamide and
Dorzolamide
34. Thiazide/thiazide
like diuretics main
indication is?
47. What is ADME
54. What is
D- > 90% plasma protein bound, diuresis adverse/side
diuretics
effect of K-
M- furosemide, bumetanide- partial hepatic diuretics, the
aldosterone
(minor), CYP2C9 (major), ethacrynic acid- antagonist drug?
55. What is
adverse/side
effect of K-
48. What is ADME
of osmotic
D- remains in extracellular space, filtered at diuretics, the
diuretics
sodium channel
15-30 mins to reduce intracranial pressure, blocker drug?
56. What is
adverse/side
effect of
49. What is ADME
vasopressin R
antagonists?
Spirinolactone Eplerenone- 50% protein bound
M-hepatic, spirin- canrenone and 7-alpha- Eplerenone?
sprinolactone (active), eplerenone- CYP3A4 57. What is the
adverse/side
Half life spirin- 1.5 hr, metabolites 7-23 hrs, effect of osmotic
diuretics?
58. What is the most
50. What is ADME
potent diuretics?
of thiazide
diuretics in
diuresis onset 1~2 hr, peak 4~6 hr, duration 59. Where does
general?
thiazide
M- chlorothiazide/hydrochlorothiazide- not diuretics act on?
60. Which diurectics
Spirinolactone because it can also bind to can cause
endocrine
effects?
51. What is
metabolic acidosis, electrolyte disturbances, 61. which diuretics
adverse/ side
has the widest
effect of CAI?
range of half
lives?
52. What is
adverse/ side
62. Which drugs
effect of loop
have vascular
diuretics?
allergy, hyperglycermia, hyperlipidemia.
63. Why is CAI not a
53. What is
strong diuretics
adverse/ side
but mild?
nephron that can reabsorb sodium back.
effect of
Also decrease level of bicarb will decrease Thiazide
diuretics?
64. Why is thiazide
more mild than
65. Why thiazide and loop
because sodium gets blocked in loop of henle and distal tubule, this cause sodium to only get reabsorb in diuretics cause
late distal tubule, where it gets exchange with potassium to get reabsorbed. As a result potassium get hypokalemia
66. Why would CAI cause
Bicarb is important in mouth to balance the acid in mouth, thus blocking it disrupt taste taste disturbances?
67. Zaraoxylyn
Metolazone/ Thiazide LikeOral/IVHypertension, mild edema

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