Microsoft word - bibliografia_científica_cervezaysalud_09 _3_.doc

Investigación Científica sobre Cerveza y Salud
González-Gross M, Lebrón MR, Marcos A. Revisión bibliográfica del consumo moderado de la cerveza sobre
la salud. Centro de Información Cerveza y Salud. 2000; E 6.

Posadas J. Estudio recopilatorio Cerveza y Salud. Centro de Información Cerveza y Salud. 1998; E 1.
Villarino AR, Martínez JR, Posadas P. Biblioteca de publicaciones científicas internacionales sobre el
consumo de la cerveza y su posible relación con la salud de la población. Centro de Información
Cerveza y Salud. 2000; E 5.

COMPOSICIÓN NUTRICIONAL

Mataix J. Tabla de composición de alimentos. Ed. Universidad de Granada. 2003; (4) 303.

Requejo A, Ortega R. Las diferencias en los hábitos alimentarios y estado nutritivo de un colectivo de
personas, en función del tipo de bebida consumida de manera habitual. Centro de Información Cerveza
y Salud. 1998; E 2.
Sendra JM, Carbonell JV. Evaluación de las propiedades nutritivas, funcionales y sanitarias de la cerveza,
en comparación con otras bebidas. Centro de Información Cerveza y Salud. 1999; E 3.

Bamforth CW. Nutritional aspects of beer: a review. Nutrition Research. 2002; 22:227-237.

APORTACIÓN CALÓRICA

Bobak M, Skodova Z, Marmot M. Beer and obesity: a cross-sectional study. European Journal of Clinical
Nutrition. 2003; 57(10):1250-53.
Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science. 2007;
318(5855):1469-72.
Loos RJ, Bouchard C. FTO: the first gene contributing to common forms of human obesity. Obesity
Reviews. 2008; 9(3):246-50
Ponsonby AL, Blizzard L, Pezic A, Cochrane JA, Ellis JA, Morley R, Dickinson JL, Sale MM, Richards SM,
Dwyer T. Adiposity gain during childhood, ACE I/D polymorphisms and metabolic outcomes. Obesity
Silver Spring. 2008; 16(9):2141-7.
Romeo J, González-Gross M, Wärnberg J, Díaz LE, Marcos A. ¿Influye la cerveza en el aumento de peso?
Efectos de un consumo moderado de cerveza sobre la composición corporal. Nutrición Hospitalaria.
2007; 22(2):223-8.

Romeo J, González-Gross M, Wärnberg J, Díaz LE, Marcos A. Contribución a la ingesta de micro y
macronutrientes que ejerce un consumo moderado de cerveza. Nutrición Hospitalaria. 2006; 21(1):84-
91
Ruggenenti P, Bettinaglio P, Pinares F, Remuzzi G. Angiotensin converting enzyme insertion/deletion
polymorphism and renoprotection in diabetic and nondiabetic nephropathies. Clinical Journal of the
American Society of Nephrology. 2008; 3(5):1511-25.
Serra LL, Aranceta J. La cerveza en la alimentación de los españoles: relación entre el consumo de cerveza y el consumo de energía y nutrientes, el índice de masa corporal y la actividad física en la población adulta española. Centro de Información Cerveza y Salud. 2003; E 11.

Strazzullo P, Iacone R, Iacoviello L, Russo O, Barba G, Russo P, D'Orazio A, Barbato A, Cappuccio FP,
Farinaro E, Siani A; Olivetti Prospective Heart Study. Genetic variation in the renin-angiotensin system and abdominal adiposity in men: the Olivetti Prospective Heart Study. Annal of Internal Medicine. 2003;
138(1):17-23.

Fujita T, Adachi J, Ueno Y, Peters TJ, Preedy VR. Chronic ethanol feeding increases 7-
hydroperoxycholesterol and oxysterols in rat skeletal muscle. Metabolism. 2002; 51(6):737-42.
Goñi I, Díaz-Rubio ME, Saura-Calixto F. Dietary fever in beer: Content, Composition, Colonic Fermentability, and contribution to the diet. Beer in Health and Disease Prevention. 2009; 28: 299.
Jiménez JP, Serrano J, Tabernero M, Arranz S, Díaz-Rubio ME, García-Diz L, Goñi I, Saura-Calixto F. Effects of grape antioxidant dietary fiber in cardiovascular disease risk factors. Nutrition. 2008; 24(7-8):646-

Saura-Calixto F, Goñi I, Martín C, Pulido R. Fibra dietética de la cerveza; contenido, composición y
evaluación nutricional. Centro de Información Cerveza y Salud. 2000; E 9.
Saura-Calixto F, García-Alonso A, Goñi I, Bravo L. In vitro determination of the indigestible fraction in foods: an alternative to dietary fiber analysis. Journal of Agricultural and Food Chemistry. 2000;
48(8):3342-7.
Saura-Calixto F, Goñi I. The intake of dietary indigestible fraction in the Spanish diet shows the limitations
of dietary fibre data for nutritional studies. European Journal of Clinical Nutrition. 2004; 58(7):1078-
82.
HOMOCISTEÍNA Y ÁCIDO FÓLICO

De Luis D, Aller R. Beer Consumption and Homocysteine. Beer in Health and Disease Prevention.
2009; 62: 615.

Mayer Jr O, Simon J, Rosovola H. A population study of the influence of beer consumption on folate and
homocysteine concentrations. European Journal of Clinical Nutrition. 2001; 55(7):605-9.

Varela-Moreiras G, Alonso E, Póo R. La determinación in Vitro y en vivo de la biodisponibilidad del ácido
fólico contenido en la cerveza. Centro de Información Cerveza y Salud. 2000; E 4.

Varela-Moreiras G, Escudero JM, Alonso-Aperte E. Homocisteína, vitaminas relacionadas y estilos de vida
en personas de edad avanzada: Estudio SÉNECA. Nutrición Hospitalaria. 2007; 22(3):363-70.

SISTEMA INMUNE

Díaz E, González-Gross M, Martínez JR, Vallejo AI, Marcos A. Estudio nutricional e inmunológico en
humanos y en animales de experimentación. Centro de Información Cerveza y Salud. 2002; E 10.
Diaz LE, Cano P, Jimenez-Ortega V, Nova E, Romeo J, Marcos A, Esquifino AI. Effects of moderate consumption of distilled and fermented alcohol on some aspects of neuroimmunomodulation. Neuroimmunomodulation. 2007; 14(3-4):200-5.
Romeo J, González-Gross M., Wärnberg J., Díaz LE, Marcos A. Effects of moderate beer consumption on blood lipid profile in healthy Spanish adults. Nutrition, Metabolism & Cardiovascular Diseases. 2008;
18(5): 365-72.
Romeo J, Wärnberg J, Díaz LE, González-Gross M, Nova E, Marcos A. Changes in the immune system after moderate beer consumption. Annals of Nutrition and Metabolism. 2007; 51(4):359-66.

Romeo J, Wärnberg J, Díaz LE, González-Gross M, Marcos A. Effects of moderate beer consumption on
first-line immunity of healthy adults. Journal of Physiology and Biochemistry. 2007; 63(2):153-9.

Romeo J, Wärnberg J, Nova E, Díaz LE, Gómez-Martinez S, Marcos A. Moderate alcohol consumption and
the immune system: a review. British Journal of Nutrition. 2007; 98 Suppl 1:S111-5.

SALUD ÓSEA: SILICIO

Albrand G, Munoz F, Sornay-Rendu E, DuBoeuf F, Delmas PD. Independent predictors of all osteoporosis-
related fractures in healthy postmenopausal women. Bone. 2003; 32(1):78-85.

Bainbridge KE, Sowers M, Lin X, Harlow SD. Risk factors for low bone mineral density and the 6-year rate
of bone loss among premenopausal and perimenopausal women. Osteoporosis International. 2004;
15(6):439-46.
Bauer DC, Browner WS, Cauley JA, Orwoll ES, Scott JC, Black DM, Tao JL, Cummings SR. Factors associated with appendicular bone mass in older women. The Study of Osteoporotic Fractures Research
Group. Annals of Internal Medicine. 1993; 118(9):657-65.

Bellia JP, Birchall JD, Roberts NB. Beer: a dietary source of silicon. Lancet. 1994; 343(8891):235.

Borah B, Dufresne TE, Chmielewski PA, Manhart MD, Watts NB. Risedronate preserves bone architecture in
postmenopausal women with osteoporosis as measured by three-dimensional microcomputed tomography.
Bone. 2004; 34(4):736-46.
Felson DT, Zhang Y, Hannan MT, Kannel WB, Kiel DP. Alcohol intake and bone mineral density in elderly men and women. The Framingham Study. American Journal of Epidemiology. 1995; 142(5):485-92.

Feskanich D, Korrick SA, Greenspan SL, Rosen HN, Colditz GA. Moderate alcohol consumption and bone
density among postmenopausal women. Journal of Women’s Health. 1999; 8(1):65-73.
Ganry O, Baudoin C, Fardellone P. Effect of alcohol intake on bone mineral density in elderly women: The
EPIDOS Study. Epidemiologie de l’Osteoporose. American Journal of Epidemiology. 2000;
151(8):773-80.
Jugdaohsingh R, O’Connell MA, Sripanyakorn S and Powell JJ. Moderate Alcohol Consumption and Increased Bone Mineral Density: Potential Ethanol and Non-ethanol Mechanisms. Proceedings of the
Nutrition Society. 2006; 65(3):291-310.

Jugdaohsingh R, Powell JJ. Moderate Beer Consumption: Effects on Silicon Intake and Bone Health. Beer in
Health and Disease Prevention. 2009; 80: 787.

Jugdaohsingh R, Anderson SH, Tucker KL, Elliott H, Kiel DP, Thompson RP, Powell JJ. Dietary silicon intake
and absorption. American Journal of Clinical Nutrition. 2002; 75(5):887-93.
Jugdaohsingh R, Tucker KL, Qiao N, Cupples LA, Kiel DP, Powell JJ. Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring
cohort. Journal of Bone and Mineral Research. 2004 Feb;19(2):297-307.

Jugdaohsingh R, Anderson SH, Tucker KL, Elliott H, Kiel DP, Thompson RP, Powell JJ. Dietary silicon intake
and absorption. American Journal of Clinical Nutrition. 2002; 75(5):887-93.

McNaughton SA, Bolton-Smith C, Mishra GD, Jugdaohsingh R, Powell JJ. Dietary silicon intake in post-
menopausal women. British Journal of Nutrition. 2005; 94(5):813-7.
MukamaL KJ, Robbins JA, Cauley. Alcohol consumption, bone density, and hip fracture among older adults: the cardiovascular health study. Osteoporosis International. 2007; 18(5):593-602.
Pedrera JD, Lavado JM, Rico H. Ingesta moderada de cerveza y masa ósea en mujeres pre, peri y postmenopásicas. Centro de Información Cerveza y Salud. 2004; E 13.

Powell JJ, McNaughton SA, Jugdaohsingh R, Anderson SH, Dear J, Khot F, Mowatt L, Gleason KL, Sykes M,
Thompson RP, Bolton-Smith C, Hodson MJ. A provisional database for the silicon content of foods in the United Kingdom. British Journal of Nutrition. 2005; 94(5):804-12.
Sripanyakorn S, Jugdaohsingh R, Elliott H, Walker C, Mehta P, Shoukru S, Thompson RP, Powell JJ. The
silicon content of beer and its bioavailability in healthy volunteers. British Journal of Nutrition. 2004.
91(3):403-9.
Sripanyakorn S, Jugdaohsingh R, Mander A, Davidson SL, Thompson RP, Powell JJ. Moderate Ingestion of
Alcohol is Associated with Acute Ethanol-Induced Suppression of Circulating CTx in a PTH-Independent
Fashion. Journal of Bone and Mineral Research. 2009.

Sripanyakorn S, Jugdaohsingh R, Elliott H, Walker C, Mehta P, Shoukru S, Thompson RP, Powell JJ. The
silicon content of beer and its bioavailability in healthy volunteers. British Journal of Nutrition. 2004;

Tucker KL, Jugdaohsingh R, Powell JJ, Qiao N, Hannan MT, Sripanyakorn S, Cupples LA, Kiel DP. Effects of
beer, wine, and liquor intakes on bone mineral density in older men and women. American Journal of
Clinical Nutrition. 2009.

Walker C, Freeman G, Jugdaohsingh R, Powell J. Silicon in beer; Origin and Concentration. Beer in Health
and Disease Prevention. 2009; 35: 367.

ALZHEIMER

González-Muñoz MJ, Meseguer I, Peña A. Posible efecto protector del silicio contenido en la cerveza en las
enfermedades neurodegenerativas. Centro de Información Cerveza y Salud. 2006; E 15.

González-Muñoz MJ, Peña A, Meseguer I. Role of beer as a possible protective factor in preventing
Alzheimer's disease. Food and Chemical Toxicology. 2008; 46(1):49-56.

Gonzalez-Muñoz MJ, Meseguer I, Sanchez-Reus MI, Schultz A, Olivero R, Benedí J, Sánchez-Muniz FJ. Beer
consumption reduces cerebral oxidation caused by aluminum toxicity by normalizing gene expression of
tumor necrotic factor alpha and several antioxidant enzymes. Food and Chemical Toxicology. 2008; 4
6(3):1111-8.
Peña A, Meseguer I, González-Muñoz MJ. Influence of moderate beer consumption on aluminium toxico- kynetics: acute study. Nutrición Hospitalaria. 2007; 22(3):371-6.

Ruitenberg A, van Swieten JC, Witteman JC, Mehta KM, van Duijn CM, Hofman A, Breteler MM. Alcohol
consumption and risk of dementia: the Rotterdam Study. Lancet. 2002;359(9303):281-6.
Stampfer MJ, Kang JH, Chen J, Cherry R, Grodstein F. Effects of moderate alcohol consumption on cognitive function in women. The New England Journal of Medicine. 2005; 352(3):245-53.

FITOESTRÓGENOS

Fanti P, Monier-Faugere MC, Geng Z, Schmidt J, Morris PE, Cohen D, Malluche HH. The phytoestrogen
genistein reduces bone loss in short-term ovariectomized rats. Osteoporosis International. 1998;
8(3):274-81.
Milligan SR, Kalita JC, Heyerick A, Rong H, De Cooman L, Keukeleire D. Identification of a potent phytoestrogen in hops (Humulus Lupulus L.) and beer. Journal of Clinical Endocrinology &
Metabolism. 1999; 84(6):2249-52.
Pedrera JD, Lavado JM, Rico H. Ingesta moderada de cerveza y masa ósea en mujeres sanas pre, peri y postmenopáusicas. Centro de Información Cerveza y Salud. 2004; E 13.

Rosenblum ER, Campbell IM, Van Thiel DH, Gavaler JS. Isolation and identification of phytoestrogens from
beer. Alcohol Clinical and Experimental Research. 1992; 16(5):843-5.

Rossemblum ER, Stauber RE, Van Thiel DH, Campbell IM, Gavaler JS. Assessment of the estrogenic activity
of phytoestrogens isolated from bourbon and beer. Alcohol Clinical and Experimental Research. 1993;
17(6):1207-9.

ANTIOXIDANTES (LÚPULO)
Arimoto-Kobayashi S, Sugiyama C, Harada N, Takeuchi M, Takemura M, Hayatsu H. Inhibitory effects of beer and other alcoholic beverages on mutagenesis and DNA adduct formation induced by several carcinogens. Journal of Agricultural and Food Chemistry. 1999; 47(1):221-30.

Becker H, Gerhäuser C, Bohr G. Acylphloroglucinol Derivatives from Hops as Anti-inflamatory Agents. Beer
in Health and Disease Prevention. 2009; 76: 753.

Ghiselli A, Natella F, Guido A, Montanari L, Fantozzi P, Scaccini C. Beer increases plasma antioxidant
capacity in humans. Journal of Nutrition and Biochemistry. 2000; 11(2):76-80.

González J, Culebras JM, Mataix J, Tuñón MJ, Sánchez S. Papel protector de los flavonoides de la cerveza
frente a las alteraciones hepáticas inducidas por estrés oxidativo. Centro de Información Cerveza y
Salud. 2003; E 13.

González ML, Muñiz P, Valls V. Actividad antioxidante de la cerveza: Estudios “in vitro” e “in vivo”. Centro
de Información Cerveza y Salud. 2001; E 8.

Lapcik O, Hill M, Hampl R, Wahala K, Adlercreutz H. Identification of isoflavonoids in beer. Steroids. 1998;
63(1):14-20.

Lugasi A, Hóvári J. Antioxidant properties of commercial alcoholic and nonalcoholic beverages. Nahrung.
2003; 47(2):79-86.

Martínez JR, Valls V, López-Jaén AB, Marín AV, Codoñer-Franch P. Effects of alcohol-free beer on lipid
profile and parameters of oxidative stress and inflammation in elderly women. Nutrition. 2009;
25(2):182-7.

Martínez JR, Valls V, Villarino A. El lúpulo contenido en la cerveza, su efecto antioxidante en un grupo
controlado de población. Centro de Información Cerveza y Salud. 2007; E 16.

Martínez JR, Villarino A, Cobo JM. Propiedades de la cerveza sin alcohol. Centro de Información Cerveza
y Salud. 2001; E 7.

Milligan SR, Kalita JC, Pocock V, Van De Kauter V, Stevens JF, Deinzer ML, Rong H, De Keukeleire D. The
endocrine ativities of 8-prenylnaringenin and related hop (Humulus Lupulus L.) flavonoids. Nutrition.
2009; 25(2):182-7.

Morales FJ. Non-specific Hydroxyl Radical Scavenging Properties of Melanoidins from Beer. Beer in Health
and Disease Prevention. 2009; 78: 765.

Muñiz P, Valls V, Perez-Broseta C, Iradi A, Climent JV, Oliva MR, Sáez GT. The role of 8-hydroxy-2'-
deoxyguanosine in rifamycin-induced DNA damage. Free Radical Biology & Medicine. 1995;
18(4):747-55.
Rivero D, Pérez-Magariño S, González-Sanjosé ML, Valls V, Codoñer P, Muñiz P. Inhibition of induced DNA oxidative damage by beers: correlation with the content of polyphenols and melanoidins. Journal of
Agricultural and Food Chemistry. 2005; 53(9):3637-42.
Saura-Calixto F, Serrano J, Pérez-Jiménez J. What Contribution Is Beer to the Intake of Antioxidant in the Diet?. Beer in Health and Disease Prevention. 2009; 42: 441.

Tagashira M, Watanabe M, Uematsu N. Antioxidative activity of hop bitter acids and their analogues.
Bioscience, Biotechnology and Biochemistry. 1995; 59(4):740-2.

Valls V, Codoñer P, González ML, Muñiz P. Biodisponibilidad de los flavonoides de la cerveza. Centro de
Información Cerveza y Salud. 2005; E 14.
Valls V, Martínez Alvarez JR, et al. El lúpulo contenido en la cerveza, su efecto antioxidante en un grupo controlado de población. Centro de Información Cerveza y Salud. 2007; E 15.

Valls V, Torres-Rodríguez MC, Muñiz P, Boix L, González-Sanjose ML, Codoñer-Franch P. alpha-Tocopherol,
MDA-HNE and 8-OHdG levels in liver and heart mitochondria of adriamycin-treated rats fed with alcohol-
free beer. Toxicology. 2008; 249(2-3):97-101

ANTIOXIDANTES (XANTHOHUMOL)

Albini A, Dell'Eva R, Vené R, Ferrari N, Buhler DR, Noonan DM, Fassina G. Mechanisms of the
antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets. Federation of
American Societies for Experimental Biology Journal. 2006; 20(3):527-9.

Allen PC. Anticoccidial effects of xanthohumol. Avian Diseases. 2007; 51(1):21-6.
Becker H, Berwanger S. Biolabeling of Xanthohumol in Hop Cones (Humulus Lupulus L., Cannabaceae) with
Stable and Rdioactive Precursors for Biosynthetic and Metabolic Studies. Beer in Health and Disease
Prevention. 2009; 81: 795.
Bolca S, Possemiers S, Maervoet V, Huybrechts I, Heyerick A, Vervarcke S, Depypere H, De Keukeleire D, Bracke M, De Henauw S, Verstraete W, Van de Wiele T. Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women. British Journal of Nutrition. 2007; 98(5):950-9.
Bracke ME, Vanhoecke BW, Derycke L, Bolca S, Possemiers S, Heyerick A, Stevens CV, De Keukeleire D, Depypere HT, Verstraete W, Williams CA, McKenna ST, Tomar S, Sharma D, Prasad AK, DePass AL, Parmar VS. Plant polyphenolics as anti-invasive cancer agents. Anti-Cancer Agents in Medicinal Chemistry.
2008; 8(2):171-85. in vivo
Carrera MP, Ramírez-Expósito MJ, Valenzuela MT, Dueñas B, García MJ, Mayas MD, Martínez-Martos JM. Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with
breast cancer induced by N-methyl-nitrosourea. Cancer Invest. 2006; 24(2):149-53.

Colgate EC, Miranda CL, Stevens JF, Bray TM, Ho E. Xanthohumol, a prenylflavonoid derived from hops
induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Cancer Letters. 2007;
246(1-2):201-9.

Dell'Eva R, Ambrosini C, Vannini N, Piaggio G, Albini A, Ferrari N. AKT/NF-kappaB inhibitor xanthohumol
targets cell growth and angiogenesis in hematologic malignancies. Cancer. 2007; 110(9):2007-11. in
Delmulle L, Bellahcène A, Dhooge W, Comhaire F, Roelens F, Huvaere K, Heyerick A, Castronovo V, De Keukeleire D. Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines. Phytomedicine. 2006; 13(9-10):732-4.
Gerhäuser C. Techniques for Assessing Anti-Cancer Effects of Beer. Beer in Health and Disease
Prevention. 2009; 90: 901.

Gerhäuser C. Phenolic Beer Compounds to Prevent Cancer. Beer in Health and Disease Prevention.
2009; 68: 669.
Gerhäuser C. Beer constituents as potential cancer chemopreventive agents. European Journal of
Cancer. 2005; 41(13):1941-54.
Gerhäuser C, Alt A, Heiss E, Gamal-Eldeen A, Klimo K, Knauft J, Neumann I, Scherf HR, Frank N, Bartsch H, Becker H. Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop. Molecular Cancer Therapeutics. 2002; 1(11):959-69.
Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB. Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells. Blood Journal. 2009;
113(9):2003-13.

Ho YC, Liu CH, Chen CN, Duan KJ, Lin MT. Inhibitory effects of xanthohumol from hops (Humulus lupulus
L.) on human hepatocellular carcinoma cell lines. Phytotherapy Research. 2008; 22(11):1465-8.
Koo JH, Kim HT, Yoon HY, Kwon KB, Choi IW, Jung SH, Kim HU, Park BH, Park JW. Effect of xanthohumol
on melanogenesis in B16 melanoma cells. Experimental and Molecular Medicine. 2008; 40(3):313-9.
Mendes V, Monteiro R, Pestana D, Teixeira D, Calhau C, Azevedo I. Xanthohumol influences preadipocyte
differentiation: implication of antiproliferative and apoptotic effects. Journal of Agricultural and Food
Chemistry. 2008; 56(24):11631-7.

Miranda CL, Stevens JF, Helmrich A, Henderson MC, Rodriguez RJ, Yang YH, Deinzer ML, Barnes DW,
Buhler DR. Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in
human cancer cell lines. Food and Chemical Toxicolgy. 1999; 37(4):271-85.
Monteghirfo S, Tosetti F, Ambrosini C, Stigliani S, Pozzi S, Frassoni F, Fassina G, Soverini S, Albini A, Ferrari N. Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-kappaB and p53 modulation. Molecular Cancer Therapeutics. 2008; 7(9):2692-702. in vivo
Monteiro R, Calhau C, Silva AO, Pinheiro-Silva S, Guerreiro S, Gärtner F, Azevedo I, Soares R. Xanthohumol inhibits inflammatory factor production and angiogenesis in breast cancer xenografts. Journal of Cellular Biochemistry. 2008; 104(5):1699-707. in vivo

Monteiro R, Faria A, Azevedo I, Calhau C. Modulation of breast cancer cell survival by aromatase inhibiting
hop (Humulus lupulus L.) flavonoids. Journal of Steroid Biochemistry and Molecular Biology. 2007;
105(1-5):124-30.

Noonan DM, Benelli R, Albini A. Angiogenesis and cancer prevention: a vision. Recent Results in Cancer
Research. 2007; 174:219-24. in vivo
Puertollano MA, Carrera MP, Puertollano E, Alvarez de Cienfuegos G, Ramirez-Expósito MJ, De Pablo MA, Martinez-Martos JM. Analysis of caspase activities in rat mammary tumours induced by N-methyl- nitrosourea. Oncology Reports. 2008; 20(3):657-62.
Rodríguez RJ, Miranda CL, Stevens JF, Deinzer ML, Buhler DR. Antiproliferative and cytotoxic effects of
prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines. Food and Chemical
Toxicology. 1999; 37(4):271-85.
Ruefer CE, Gerhäuser C, Frank N, Becker H, Kulling SE. In vitro phase II metabolism of xanthohumol by human UDP-glucuronosyltransferases and sulfotransferases. Molecular Nutrition & Food Research.
2005; 49(9):851-6.
Sainz RM, Reiter RJ, Tan DX, Roldan F, Natarajan M, Quiros I, Hevia D, Rodriguez C, Mayo JC. Critical role of glutathione in melatonin enhancement of tumor necrosis factor and ionizing radiation-induced apoptosis in prostate cancer cells in vitro. Journal of Pineal Research. 2008; 45(3):258-70.

Stevens JF, Taylor AW, Deinzer ML. Quantitative analysis of xanthohumol and related prenylflavonoids in
hops and beer by liquid chromatography – tandem mass spectrometry. Journal of Chromatography A.
1999; 832(1-2):97-107.
Stevens JF, Taylor AW, Clawson JE, Deinzer ML. Fate of xanthohumol and related prenylflavonoids from hops to beer. Journal of Agricultural and Food Chemistry. 1999; 47(6):2421-8.

Tagashira M, Watanabe M, Uemitsu N. Antioxidative activity of hop bitter acids and their analogues.
Bioscience, Biotechnology and Biochemistry. 1995; 59(4):740-2.

Yasukawa K, Takeuchi M, Takido M. Humulon, a bitter in the hop, inhibits tumor promotion by 12-O-
tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Oncology. 1995;
52(2):156-8.

Yilmazer M, Stevens JF, Deinzer ML, Buhler DR. In vitro biotransformation of xanthohumol, a flavonoid
from hops (Humulus lupulus), by rat liver microsomes. Drug Metabolism and Disposition. 2001;
29(3):223-31.

PROTECCIÓN CARDIOVASCULAR
Beulens JW, van den Berg R, Kok FJ, Helander A, Vermunt SH, Hendriks HF. Moderate alcohol consumption and lipoprotein-associated phospholipase A2 activity. Nutrition, Metabolism &
Cardiovascular Diseases. 2008; 18(8):539-44.
Beulens JW, Sierksma A, Schaafsma G, Kok FJ, Struys EA, Jakobs C, Hendriks HF. Kinetics of homocysteine metabolism after moderate alcohol consumption. Alcoholism: Clinical and Experimental Research.
2005; 29(5):739-45.

Bobak M, Skodova Z, Marmot M. Effect of beer drinking on risk of myocardial infarction: population based
case-control study. British Medical Journal. 2000; 320(7246):1378-9.

Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, Deanfield JE. Non-
invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992;
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