Polyclonal anti-eif2s1

BOSTER BIOLOGICAL TECHNOLOGY Co.,Ltd.
40459 Encyclopedia Circle, Fremont, CA 94538
Tel: (510)445-1120, (510)445-1157 Fax: (510)445-1163 Email Web Polyclonal Anti- FMO3 Antibody
Catalog Number: PA1764
Gene Name
Recommended Protein Name
Dimethylaniline monooxygenase [N-oxide-forming] 3 Specificity
No cross reactivity with other proteins. Purification
Reacts with: rat
Predicted to work with: human, mouse
A synthetic peptide corresponding to a sequence at the N-terminus of human Immunogen
FMO3(76-90aa DDFPNFMHNSKIQEY), different from the related rat sequence by one amino acid, and from the related mouse sequence by two amino acids. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Contents
Tested Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users. Reconstitution: 0.2ml of distilled water will yield a concentration of 500μg/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at
Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit FMO3(Flavin-containing Monooxygenase 3) is anthat in humans is encoded by the FMO3The mammalian flavin-containing monooxygenases (FMO) represent a multigene family whose gene products are localized in the endoplasmic reticulum of many tissues. The FMO3 gene contains 1 noncoding and 8 coding exons. The FMO3 gene is mapped on 1q24.3. Using quantitative RNase protection assays, FMO3 is present in low abundance in fetal liver and lung and in adult kidney and lung, and in much greater abundance in adult liver. By Western blot analysis of human liver microsomal samples ranging from 8 weeks gestation to 18 years of age, FMO1 is the major fetal isoform and FMO3 is the major adult isoform. FMO3 was expressed at intermediate levels until 11 years of age when a gender-independent increase in FMO3 expression was observed during puberty. Sufferers of trimethylaminuria may display a reduced ability to metabolize substrates for FMO3 such as nicotine. FMO3 metabolizes a number of drugs, including amphetamine, clozapine, deprenyl, metamphetamine, tamoxifen, ethionamide, thiacetazone, and sulindac sulfide. Reference
1. Akerman, B. R., Chow, L., Forrest, S., Youil, R., Cashman, J., Treacy, E. P. Mutations in the flavin-containing monoxygenase (sic) form 3 (FMO3) gene cause trimethylaminuria, fish odour syndrome. (Abstract) Am. J. Hum. 2. Cashman, J. R., Zhang, J. Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation. Drug Metab. Dispos. 30: 1043-1052, 2002. 3. Dolphin, C. T., Janmohamed, A., Smith, R. L., Shephard, E. A., Phillips, I. R. Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome. Nature Genet. 17: 491-494, 1997. FOR RESEARCH USE ONLY. NOT FOR DIAGNOSTIC AND CLINICAL USE.

Source: http://www.bosterbio.com/v/vspfiles/pdf/PA1764_DS.pdf