Born on October 7th, 1950 Deputy Director of the Circulation, metabolism and nutrition institute since April 2008 Degrees and qualifications Doctor of Medicine, PhD in sciences, Hospital practitioner and university professor Qualifications in practice: Internal medicine, intensive care, nutrition Professional experience 1968
Assistant Head of Clinic, intensive care unit, Grenoble university hospital
Post-doctorat : Laboratory of Biochemistry, section of Medical Enzymology, University of Amsterdam (Prof Dr JM Tager)
Biophysics laboratory assistant, Grenoble university hospital
Professor of therapy/intensive care, Grenoble university hospital
Appointment to the French National Universities Board (CNU) (44-04 Nutrition)
Professor of nutrition, Grenoble university hospital
Director of unit 884 Inserm/Joseph Fourier University on fundamental and applied bioenergetics
Head of the Human nutrition department, French National Institute for Agricultural Research (INRA), Paris
Election to the CNU (Chairman of sub-department 44-04 Nutrition)
Scientific Director for Human nutrition and food safety, INRA, Paris
Distinctions 1980 First Thesis Prize, Grenoble University 2001 Honoris Causa Doctor, University of Bucharest, 2005 Ajinomoto prize 2006 Benjamin Delessert prize 2009 Foreign professor, Universitas Indonesia, Jakarta, Indonesia Recent publications
15. Taleux N, Guigas B, Dubouchaud H, Moreno M, Weitzel JM, Goglia F, Favier R, Leverve XM. High expression of thyroid hormone receptors and mitochondrial glycerol-3-phosphate dehydrogenase in the liver is linked to enhanced fatty acid oxidation in Lou/C, a rat strain resistant to obesity. J Biol Chem 2009;284:4308-4316. 14. Ichai C, Armando G, Orban JC, Berthier F, Rami L, Samat-Long C, Grimaud D, Leverve X. Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients. Intensive Care Med 2009;35:471-479. 13. Cano NJ, Fouque D, Roth H, Aparicio M, Azar R, Canaud B, Chauveau P, Combe C, Laville M, Leverve XM. Intradialytic parenteral nutrition does not improve survival in malnourished hemodialysis patients: a 2-year multicenter, prospective, randomized study. J Am Soc Nephrol 12. De Oliveira F., Chauvin C, Ronot X, Mousseau M, Leverve X, Fontaine E. Effects of permeability transition inhibition and decrease in cytochrome c content on doxorubicin toxicity in K562 cells. Oncogene 2006;25:2646-2655. 11. Detaille D, Guigas B, Chauvin C, Batandier C, Fontaine E, Wiernsperger N, Leverve X. Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process. Diabetes 2005;54:2179-2187. 19. Korach-Andre M, Roth H, Barnoud D, Pean M, Peronnet F, Leverve X. Glucose appearance in the peripheral circulation and liver glucose output in men after a large 13C starch meal. Am J Clin Nutr 2004;80:881-886. 9. Batandier C, Leverve X, Fontaine E. Opening of the mitochondrial permeability transition pore induces reactive oxygen species production at the level of the respiratory chain complex I. J Biol Chem 2004;279:17197-17204. 8. Nogueira V, Rigoulet M, Piquet MA, Devin A, Fontaine E, Leverve XM. Mitochondrial respiratory chain adjustment to cellular energy demand. J Biol Chem 2001;276:46104-46110. 7. Ichai C, Guignot L, El-Mir MY, Nogueira V, Guigas B, Chauvin C, Fontaine E, Mithieux G, Leverve XM. Glucose 6-phosphate hydrolysis is activated by glucagon in a low temperature- sensitive manner. J Biol Chem 2001;276:28126-28133. 6. Sibille B, Filippi C, Piquet MA, Leclercq P, Fontaine E, Ronot X, Rigoulet M, Leverve X. The mitochondrial consequences of uncoupling intact cells depend on the nature of the exogenous substrate. Biochem J 2001;355:231-235. 5. Ichai C, El-Mir MY, Nogueira V, Piquet MA, Chauvin C, Fontaine E, Leverve XM. Exogenous Mg- ATP induces a large inhibition of pyruvate kinase in intact rat hepatocytes. J Biol Chem 2001;276:6398-6403. 4. El-Mir MY, Nogueira V, Fontaine E, Averet N, Rigoulet M, Leverve X. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem 2000;275:223-228.
3. Chiolero R, Tappy L, Gillet M, Revelly JP, Roth H, Cayeux C, Schneiter P, Leverve X. Effect of major hepatectomy on glucose and lactate metabolism. Ann Surg 1999;229:505-513. 2. Cano N, Catelloni F, Fontaine E, Novaretti R, di Costanzo-Dufetel J, Reynier JP, Leverve XM. Isolated rat hepatocyte metabolism is affected by chronic renal failure. Kidney Int 1995;47:1522- 1527. 1. Pison CM, Chauvin C, Fontaine E, Catelloni F, Keriel C, Paramelle B, Leverve XM. Mechanism of gluconeogenesis inhibition in rat hepatocytes isolated after in vivo hypoxia. Am J Physiol 1995;268:E965-973.
Ref.: LDE/022009039/cm Declaration on banning Bisphenol A in babies’ bottles Dear Member of the European Parliament, We are writing on behalf of consumer, environmental and health NGOs to ask for your support in relation to the attached Written Declaration on banning Bisphenol A in babies’ bottles (Nr. 0106/2008). This declaration has been tabled by MEPs Hanne Dahl, Chris
National Asthma Education & Prevention Program – Expert Panel Report 3 2007 - Guidelines for the Diagnosis and Management of Asthma Highlights of Major Changes in the EPR-3 The following are highlights of major changes in the EPR-3. Many recommendations were updated or expanded based on new evidence. See EPR—3: Full Report 2007 for key differences at the beginning of each section and