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Almost half a mil ion people in the UK live with Alzheimer's disease. Here we explain causes and symptoms and suggest activities that may help lower your risk. This condition is the most common cause of dementia and is characterised by the
formation of protein ‘plaques’ and ‘tangles’ in the brain, which kill off brain cells. It
is also a progressive disease, meaning the extent of the damage gradually
increases over time – and the symptoms also therefore inevitably worsen. The
name of the disease comes from the German neurologist Alois Alzheimer, who
first described it in 1906. Today it affects around 496,000 people in the UK,
according to the Alzheimer’s Society, a UK-based charity with 25,000 members.
What causes it?
No one single factor has been identified as a cause of Alzheimer’s disease.
However, it is likely that an individual’s overall risk is related to a combination of
factors including:
Age is the most important known risk factor. One in 14 people over the age of 65 and one in six over the age of 80 are affected by dementia. The influence of inherited genes seems to be relatively small in the vast majority of cases in older people. However, in some families where the disease appears relatively early in life, there appears to be clear evidence for the role of genetic inheritance. There are more than 17,000 people under 65 with dementia in the UK and the Alzheimer’s Society says this figure is likely to be an underestimate. Smoking, having high blood pressure, high cholesterol levels or diabetes all raise the risk. A study of 2,587 adults published in the journal Neurology in 2011 by researchers at Kyushu University in Japan found that brain plaques were found in
autopsies of 86 percent of people who had high cholesterol in adulthood
compared to 62 percent of people with low cholesterol.
It has also been suggested that having an active life with many interests and
hobbies may reduce the risk, as may a higher level of education. A study of 1,433
elderly people by La Colombière Hospital in Montpellier, France, published in the
British Medical Journal in 2010, found that a good education could cut the risk of
Alzheimer’s by 18 percent.
People with Down’s syndrome who live into their 50s or beyond are at high risk
due to their chromosomal abnormality. Anyone who has suffered severe head or
whiplash injuries and boxers who receive many punches to the head also appear
to be at increased risk
How can I lower my risk of Alzheimer’s disease?
Alzheimer’s Research UK, the country’s leading dementia research charity,
recommends the following measures to keep healthy and reduce your risk:
Exercising regularly; not smoking; achieving and maintaining a healthy weight;
controlling high blood pressure; reducing your cholesterol level; controlling your
blood glucose if you have diabetes; eating a healthy, balanced diet with lots of
fruit and vegetables and low amounts of saturated fat; only drinking alcohol within
the recommended limits
What are the symptoms?
People who develop Alzheimer’s disease tend to show a variety of symptoms that
can prove devastating for them and their families. Typical early symptoms
Regularly forgetting recent events, names and faces Regularly misplacing items or putting them in odd places Disorientation, especially away from your normal surroundings Reduced judgement such as being unaware of danger Mood or behaviour problems such as apathy, irritability, or losing confidence.
Symptoms worsen as the disease progresses. Sufferers may have problems with
everyday tasks such as counting loose change or working a TV remote control.
Communication problems or loss of confidence can lead to sufferers becoming
more withdrawn and eventually they will need help with all their daily activities.
How can Alzheimer’s disease be treated?
At present there is no cure, but there are drug treatments that can temporarily
alleviate some symptoms or slow their progression in some people.
People with Alzheimer’s have a shortage of a chemical called acetylcholine,
which is involved in sending messages around the brain. Aricept, Exelon and
Reminyl are three drugs that work by maintaining existing supplies of this
chemical. The National Institute for Health and Clinical Excellence (NICE)
recommends them as options for people in the mild-to-moderate stages of the
disease. Side effects are usually minor but may include diarrhoea, nausea,
insomnia, fatigue and loss of appetite.
Ebixa is the only drug recommended for people in both the moderate and severe stages of the condition. It works by blocking a messenger chemical called glutamate, which is released in damagingly large amounts. Side effects may include dizziness, headaches and tiredness and, on rare occasions, hallucinations or confusion. These drugs may stabilise some of the symptoms of Alzheimer’s disease, typically for six to 12 months or longer.  


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