Läkemedelsföretagen tvekar ofta inför att satsa på ny antibiotika för att det inte är tillräckligt lönsamt, men de ska nu ges ekonomiska morötter generisk augmentin Ofta fås en bättre/snabbare absorption när läkemedel tas på fastande mage men för vissa läkemedel är det önskvärt att minska risken för biverkningar från mag-tarmkanalen genom att läkemedlet tas tillsammans med föda.
Microsoft word - clinical laboratory sciences.doc
DEPARTMENT OF CLINICAL LABORATORY SCIENCES Research Report 2004 Division of Chemical Pathology
(Including the Chemical Pathology sections of Groote Schuur Hospital and Red Cross War Memorial Children’s Hospital) Head of Division: Associate Professor H.E. Henderson (Acting Head) Divisional Profile
The Division of Chemical Pathology and the NHLS offers a comprehensive dedicated routine service to both the adult and paediatric patients attending the Groote Schuur and Red Cross Children’s Hospitals. It participates actively at the laboratory/ward interface by attendance at ward rounds and clinical meetings. There is a strong specialist diagnostics and research focus on metabolic disorders of acquired and familial aetiology. Teaching commitments address both undergraduate and postgraduate needs, with several MSc, PhD and MMed students under current supervision. Research activities cover the biochemical mechanisms of ion and drug pumps, the identification of new drug targets in Tuberculosis and Leishmaniasis, the molecular genetics of inherited metabolic disorders, mitochondrial myopathies and erythrocyte antioxidant biochemistry. Divisional Statistics Permanent and Long-term Contract Staff
Associate Professors Total 20
Students Doctoral
Undergraduate 159 Total 170
Research Fields and Staff Permanent Staff
A/Professor Howard E. Henderson Chief Specialist Scientist; biochemical diagnosis of diseases of sick children; genetics of hyperlipidaemia; tuberculosis; galactosaemia; and cystic fibrosis; inherited metabolic disease; primary immunodeficiencies; post graduate teaching A/Professor David B. McIntosh Chief Specialist Scientist; ion pumps and ABC transporters; P-type ATPase; calcium- ATPase; multidrug resistance P-glycoprotein; flavonoids; site-directed mutagenesis; photoaffinity labelling; malaria; post graduate teaching A/Professor Daan J. Steenkamp biochemical parasitology, enzymes in the metabolism of the trypanosomatids and mycobacteria as potential drug targets, thiol metabolism in pathogens; post graduate teaching Dr Peter A. Berman Principal Specialist; carbohydrate-deficient transferrin as a biochemical marker of alcoholism, red cell chemistry and biochemistry, urate metabolism, metabolic disorders, undergraduate and post graduate teaching Dr Heleen Vreede Senior Specialist; oversees routine laboratory service at GSH; method development; information technology; post graduate teaching Dr Wessel Meyer Specialist; oversees routine laboratory service at RXH; calcitonin and CRP in paediatric practice; snake bite; undergraduate and post graduate teaching Dr Judy A. King Principal Specialist Scientist; hypertension; renin; aldosterone; sodium channel mutations; routine diagnostic reviewing; post graduate teaching Dr E. Patricia Owen Principal Specialist Scientist; inherited metabolic disease; homocysteine; mitochondrial DNA mutations; TPMT mutations; urea cycle disorders; hypertension; preelampsia, epithelia sodium channel mutations; post graduate teaching Ms Felicity Leisegang Medical Scientist; molecular genetics of galactosaemia; spinal muscular atrophy; cystic fibrosis; application of PCR to genetic screening; post graduate teaching Honorary Professors
Emeritus Professor Eric Harley purine and pyrimidine metabolism; comparative biology of red cell antioxidant systems Divisional Contact Details Postal Address: Division of Chemical Pathology, University of Cape Town Medical School, Observatory, 7925 Telephone: (SA) (21) 406 6185 Fax: (SA) (21) 448 8150 E-mail: [email protected] CLINICAL LABORATORY SCIENCES DIVISION OF FORENSIC MEDICINE AND TOXICOLOGY
(Including the Gender, Health and Justice Research Unit) Head of Division: Professor L.J. Martin Divisional Profile
A range of activities related to the role of Forensic Medicine in public policy and health promotion are being pursued. These relate specifically to violence against women and children, the role of drugs and toxins in deaths, and firearm injuries. The provision of a sustainable database on violence and injury in the Cape Town Metropole is being implemented as an urgent research priority. Divisional Statistics
Permanent and Long-term Contract Staff
Chief Specialist/Professor
Specialists 1 Registrars 2 Principal Medical Officer (part-time)
Total 9
Students
Undergraduate fourth year
Final year LLB students (Medicina Forensis course)
Total 190
Research Fields and Staff
Permanent Staff
Professor L.J. Martin management protocols for rape survivors; domestic homicide; monitoring implementation of rape law reforms; domestic violence guidelines for the health sector; epidemiology of female murder Dr D. Lourens
undetermined causes of death; deaths related to traditional medicine; drug related death Dr Y.Y. van der Heyde the effects of pre-natal alcohol exposure; SIDS; paediatric mortality
firearm fatalities and final judicial outcome Divisional Contact Details
Postal Address: Division Forensic Medicine and Toxicology, Faculty of Health Sciences, Anzio Road, Observatory, 7925 Telephone: SA (21) 406 6412 Fax: SA (21) 448 1249 E-mail: [email protected] GENDER, HEALTH AND JUSTICE RESEARCH UNIT
Director: Lillian Artz Executive Director of Unit: Professor Lynette Denny (Department of Obstetrics and Gynaecology) Unit Profile
The mission of this Unit is to improve service provision to victims of violence against women in South Africa through research, advocacy and education. Drawing together established researchers with a strong record of social-action research in disciplines including law, criminology, forensic sciences and pathology, gynecology, and psychology, this Unit is the first of its kind in South Africa to respond to the pressing need for research and interventions that crosses disciplines in support of our efforts to address the alarmingly high levels of violence against women in this country. The Unit fulfils its mission by conducting rigorous evidence-based research into: South African women’s experiences of sexual and gender-based violence; The responses of women, their communities and the criminal justice, health, and welfare
The intersections and disjunctures between health and criminal justice responses to
The developmental context in which violence occurs, and the role of violence in
perpetuating women’s under-development;
The implementation difficulties of translating ‘law on paper’ into ‘law in practice’ in health,
criminal justice and medico-legal settings;
The development of indicators for monitoring the implementation of progressive
legislation and compliance by criminal justice and health sector personnel with statutory duties;
International and local models of best practice for addressing violence against women. Unit Staff Research Staff
Research Fields and Staff Lillian Artz criminology; feminist legal theory; women and law reform; sexual offences; domestic violence; commercial sex work; research ethics; HIV Dee Smythe rule of law; violence against women; human rights; women and law reform; development Kelley Moult forensic criminology; domestic violence; informal justice Katie Doolan crime and violence prevention; violence against women; HIV Ayesha Sasman sexual offences; HIV and post-exposure prophylaxis; mental health consequences of rape and HIV Nomthandazo Kate Makeleni sexual offences; HIV and post-exposure prophylaxis; mental health consequences of rape and HIV Fazielah Bartlett sexual offences; HIV and post-exposure prophylaxis; mental health consequences of rape and HIV Tandie Jostina Fipaza sexual offences; HIV and post-exposure prophylaxis Unit Contact Details
Postal Address: H52 Old Main Building, Groote Schuur Hospital, Observatory, 7935 Telephone: SA (21) 406 6022/3 Fax: SA (21) 406 6020 E-mail: [email protected] or [email protected] Webpage: http://www.uct.ac.za/generic.php?m=/departments/genhealthjust/index.php CLINICAL LABORATORY SCIENCES DIVISION OF HAEMATOLOGY Head of Division: Professor N. Novitzky Divisional Profile The Division of Haematology at Groote Schuur Hospital is a complex unit with multidisciplinary activities that include outpatient clinics, admission beds as well as diagnostic and research laboratories. The clinical services are organised under the umbrella of the Department of Internal Medicine, while the diagnostic sections are under the broader organisation of the Department of Laboratory Medicine and NHLS. Patients with elaborate diagnostic problems, bone marrow failure or requiring stem cell transplantation are referred from all provinces; particularly the Northern and Eastern Cape and occasional y we receive referrals from foreign institutions in Sub-Saharan Africa. More recently this Division has undergone a significant transformation this year. The routine section of the laboratories that is under the control of the National Health Laboratory Service has now been rationalized and relocated into the C-floor of the hospital providing a multi- disciplinary centralized laboratory service. This physical separation from the clinical section is likely to substantially challenge the close physical and interpersonal interaction between clinical and laboratory professionals, which for many years has maintained a unified discipline. The service laboratories have been under considerable strain due to staff shortages. In the academic section, this year again, no equipment budget was available to replace critical diagnostic instruments. On a more positive note, funding has now been made available for the creation of a scientist post under the university establishment to expand our strong academic roots. The task of this scientist will be to pursue with diligence further research into the area of haematopoietic stem cell biology both at the basic sciences level in the area of stem cell transplantation and into the various forms of application to improve the understanding and treatment for haematological malignancies. Divisional Statistics Permanent and Long-term Contract Staff UCT Students Doctoral 4 Masters 8 Honours 1 Postdoctoral 1 Undergraduate 375 Total 389
Research Fields and Staff Permanent Staff Professor N. Novitzky haematopoietic stem cell biology; clonogenic assays; haematopoietic stem cell transplantation; immune reconstitution; haematological malignancies Dr Cecile du Toit haematopoietic stem cell transplantation; haematological malignancies; haemophilia Dr Jill Finlayson molecular biology of neoplasia: chronic myelogenous leukaemia; coagulation abnormalities Dr Gideon Hanekom molecular detection of minimal residual disease in patients with solid tumours (in specific breast cancer and melanoma) leukemias, lymphomas and patients with myelodysplastic syndromes; immunotherapy of such cancers; molecular pathogenesis of these cancers Dr Andrew McDonald haemophilia; thrombophilia; stem cell transplantation Contract Staff Ms Rygana Mohamed cellular biology of neoplasia; clonogenic assays Divisional Contact Details Postal Address: Division of Haematology, Room 6.06, Chris Barnard Building, Anzio Road, Observatory, 7925 Telephone: SA (21) 406 6154 or 404 3073 Fax: SA (21) 448 8607 E-mail: [email protected] CLINICAL LABORATORY SCIENCES DIVISION OF HUMAN GENETICS
(Including the MRC/UCT Human Genetics Research Unit and the CANSA Colorectal Cancer Research Consortium) Head of Division: Professor Raj S. Ramesar Divisional Profile The Division, which remains one of only two HPCSA-recognised training centres nationally, has strengthened its clinical base with two senior registrars successfully completing the Medical Genetics examinations within the College of Medicine. In recognition of international trends towards a high quality service incorporating genetic counsel ing for individuals with genetic/inherited disorders, an HPCSA-accredited MSc (Genetic Counselling) programme was established in 2003. A major aspect of the Division’s research agenda is to the identification of genes underlying disease in South African populations. These findings are meant to inform patient care and management. The Genomic Platform, for high-throughput genetic analysis involving genotyping, mutation detection and DNA sequencing, is now operational and has increased the workload within the Unit while offering spare capacity to other researchers in the Faculty of Health Sciences at UCT and the Western Cape, generally. The numbers of registered postgraduate students is unprecedented (overall this includes up to 6 BSc (Med) Hons, 5 MSc and 5 PhD students). A supportive environment has led to five postdoctoral researchers being accommodated and developed within the research facility. Apart from teaching in the medical undergraduate programme, courses are provided within the following programmes: BSc (Med) Hons, Medical Genetics subspecialist training and MSc(Genetic Counselling). In addition, the Division has an active academic programme which is comprised of CPD-accredited weekly journal clubs (Monday mornings), seminars (Tuesday midday) and clinical ‘grand rounds’ (Tuesday afternoon). Furthermore, researchers from other departments and other universities have been attracted to seek accommodation and to conduct their research in the Division and take advantage of the Human Genetics expertise and technology therein. The ongoing Retinal Disorders research project has resulted in a large and invaluable genetic registry. The most successful aspect of this project has been the recent identification of the gene underlying a dominant form of retinitis pigmentosa, which we first mapped to chromosome 17 in 1995 (Rebello et al., 2004). Research on the South African mutation, in a collaborators lab, showed promise for a novel therapeutic intervention in individuals know to be carrying the mutation. A clinical trial is currently under review. Following the identification of genetic defects underlying disease, internationally-vetted protocols have been developed for delivering diagnostic and predictive genetic testing for this group of genetic disorders. Development of such a protocol has involved active interaction, discussion and debate with patient support groups, the professional clinical care-providing fraternity, and the international RDD research community. The Colorectal Cancer Research Consortium (under the directorship of RR) had previously described a substantial burden of disease along the west coast of South Africa, due to a founder mutation. Interesting ‘anthropogenetic’ work revealed that the mutation arose some 18 generations ago. Further work in this homogeneous cohort showed that a range of additional genetic changes (modifiers) influenced the age of onset and progression of
disease. A comprehensive clinical gastroenterological screening programme in the Northern Cape has been developed on the back of the genetics research and service. Individuals shown to harbour disease-predisposing mutations are very important in testing a range of variables. The project is in the final stages of implementing the South African arm of the international CAPP (Concerted Action Polyp Prevention) study on diet-based modification of cancer risk. This work (which is not directly linked to any pharmaceutical company, but the British MRC) was attracted to South Africa because of the international publicity around the large cohort of South African families with familial colorectal cancer, in whom the predisposing genetic defect has been identified within the Division. This project is evolving naturally into other familial cancers; this niche area is going to be extremely valuable for South Africa. All of the above research has been supported by the MRC, Retina South Africa, Cansa and THRIP. The successes within the Foetal Alcohol-Related Research programme, established within the high-risk communities in the Western Cape have matured to the point of applying a substantial R01 grant through the National Institutes of Health (specifically the NIAAA). Divisional Statistics
UCT Staff
Administrative and Secretarial Staff (1Xp/T)
GSH Personnel
GSH/UCT Personnel
NHLS Personnel
Honorary Staff
Students
PhD 5 Masters 5 Honours 3 Total 20
Research Fields and Staff
Professor Raj S. Ramesar Head of Division and personal chair, Director: MRC Human Genetics Research Unit; Director: Cansa’s Colorectal Cancer Research Consortium; genetics of psychiatric disorders; genetics of retinal degenerative disorders, molecular genetics of complex disorders Dr Rik de Decker Senior Specialist: 22q Deletion syndrome; fetal alcohol syndrome; SANTA study (Aetiology of Tetralogy of Fallot), breast cancer, HIV and amniocentesis Associate Professor Jacquie Greenberg Head of Molecular Genetic Services: retinal degenerative disorders; genetics of neurological disorders; neuromuscular disorders Associate Professor Bongani Mayosi molecular genetics of inherited cardiomyopathies Dr S. Bardien Postdoctoral fellow; genetics of hypertension and complex disorders Emeritus Professor Peter Beighton genetics of connective tissue disorders Dr R. Goliath Specialist scientist; genetics of neuromuscular diseases
Dr L. Matolweni Postdoctoral fellow; genetics of cardiovascular diseases Dr Ekow Oppon Postdoctoral fellow; development of bioinformatic tools for the identification of disease susceptibility genes Dr George Rebello Scientific Officer: bioinformatics; retinal degenerative disorders (RP17); development of a genomics biotechnological platform Ronald Smart Head of Cytogenetic Service; chromosomal rearrangements and the 22q deletion syndrome Professor Denis Viljoen (Honorary Research Associate) Fetal Alcohol Syndrome Divisional Contact Details
Postal Address: Division of Human Genetics, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, 7925, Observatory Telephone: SA (21) 406 6297 Fax: SA (21) 447 7703 E-mail: [email protected] CLINICAL LABORATORY SCIENCES DIVISION OF IMMUNOLOGY
(Including the MRC/UCT Immunology of Infectious Diseases Unit) Head of Division (Acting): Professor Lafras Steyn Divisional Profile 2004 has seen our MRC Unit on “Immunology of Infectious Disease characterized by high productivity with 18 international peer reviewed publications. We have maintained and extended our excellent international and local reputation in infectious diseases as well as gene targeting technology. Some of our mouse models are unique world wide, which explains a high proportion of international funding due to much foreign collaboration. The director is currently involved in seventy plus international collaborations, most of them highly productive and successful. Excitingly an MRC evaluation of “excellent” resulted in a renewal of our unit status for another five year cycle. As a member of UCT’s new Institute for Infectious Immunology and Molecular Medicine (IIDMM), we recently moved to new laboratories with expanded space and a vibrant scientific environment. Major breakthrough and success resulted from the first inducible and cell type-specific gene deficient mouse models ’Made in South Africa’ published in the high impact journal - Immunity (Herbert et al, 2004) and the – Journal of Immunology (Seki et al, 2004). We succeeded with a new technological approach to autovaccinate, to protect against autoimmune and infectious diseases. We were able to cure experimental autoimmune encephalitis (Uyttenhove, et al, 2004), a model for multiple sclerosis and protected against cutaneous leishmaniasis (Arendse et al, 2005). In tuberculosis we demonstrated that adaptive immunity to mycobacterial infection is not necessarily dependent on innate immunity, induced by Toll like receptor, published in the high impact – Journal of Clinical Investigation (Fremond et al, 2004). Impact on research output These unique mouse models are applicable in many biological fields with our focus on experimental models for human diseases. Funding/Grants: As a consequence, we were again able to attract substantial financial support from the USA (NIH/SCOR), Belgium (Flemish/NRF co-operation, Germany (DFG/BMZ/NRF co-operation, France (PICS, UK (The Wellcome Trust), NRF (South Africa) in addition to significant (10% of total income) MRC support. Capacity development / strengthened research/ Collaboration Having established a “world class” Division and MRC unit with a productive and vibrant “mix” of International and national researchers has been satisfying. Highly reputed and well-known scientists from across the globe are visiting us and broaden and challenge our minds with their high caliber ideas. PAUSET guidelines were followed. An exciting achievement is the recently awarded Bilateral Program grant from the Royal Society, UK and NRF, SA on the “Immunology in parasitic diseases”, with strong capacity development and exchange program for previously disadvantaged students. Population group and gender composition: More than 50% of our team members are from previously disadvantaged backgrounds and 50% to 60% are female. Divisional Statistics Permanent and Long-term Contract Staff
Students
Postdoctoral 5 Doctoral 12 Masters 4 Other 4 Total 25 Research Fields and Staff
F. Brombacher the role of cytokines in human infectious diseases; vaccine and drug development in African Trypanosomiasis, tuberculosis, Leishmaniasis, Bilharzia and other Helminth infections; the macrophage effector killing genes in Listeriosis and Tuberculosis B. Ryffel TB; HIV; vaccine P. Potter allergic responses A. Lopata identification specific allergens; Anasikis pegreffi P. Burger fibroblast growth factor; prostatic stem cells ID E.L. Wilson balance VEGF/angiopoietin expression E. du Toit transplantation, population genetics; HLA B. Nurse
cytokine profiles D. Herbert analysis of cell-specific IL-4 receptor alpha knock out mice in immunity against Schistosoma mansoni S. Magez Trypanosomiasis (human sleeping sickness) M. Radwanska Trypanosomiasis (human sleeping sickness) A. Marion cytokines and stress proteins involved in TH1 versus TH1 responses in atopy N. Nieuwenhuizen host protective Immunity to the food born parasite ANISAKIS Pegreffi with focus on the immunoregulatory role of IL-4 and IL-13 using IL-4α receptor deficient mice D. Georg detection of aerosolized seafood allergens in environmental samples from a seafood processing factory R. Baartjies occupational risk factors and interventions for reducing the incidence of allergy and asthma among bakery workers M. Drennan TB/Trypanosomiasis W. Horsnell Nippostrongylus brasiliensis infection R. Guler investigate using 4 different pathogens, i.e. Listeria monocytogenes, mycobacteria tuberculosis, mycobacteria bovis BCG, and Leishmania major S Joseph Schistosoma Mansoni; identification of genes involved in type2 granuloma formation A. Cutler role of IL-4 /13 in Leishmania Associate Professor Gordon Brown innate immunology Janet Willment Postdoctoral fellow; characterization of the Human β-Glucan Receptor, Dectin-1 Kevin Dennehy Postdoctoral fellow; Dectin-1 signal transduction pathways Elwira Pyz Postdoctoral fellow characterization of the Myeloid Inhibitory C-Type Lectin Receptor, MICL
Vicky Tsoni Postdoctoral fellow; role of Dectin –1 in fungal infection Cristal Huysamen characterization of novel C-type lectin receptors Research Associates Dr Professor Bernhard Ryffel TB; HIV; vaccine Distinguished Visitors
Mary Phillips Wel come Trust Hans Haagen Welcome Trust Howard Engers
AHRI, Addis Ababa, Ethiopia Gerhard Walzel
University of Stellenbosch Kim Taversham
University of the Witwatersrand Stefan Kaufmann
London School, UK HIV/TB Workshop 1 – 7 December 2004 Martin Bachman Cytos Biotech, Zurich, Switzerland Louis Montaner
NIV SA Divisional Contact Details
Postal Address: Division of Immunology, IIDMM, Level One, Room S 1.27, Wernher Beit South, Medical School, Observatory, 7925 Telephone: SA (21) 406 6616/6147 Fax: SA (21) 406 6029 E-mail: [email protected]
CLINICAL LABORATORY SCIENCES DIVISION OF MEDICAL BIOCHEMISTRY (Including the MRC/UCT Oesophageal Cancer Research Group and the MRC/UCT Research Group for Receptor Biology) Head of Division: Professor M. Iqbal Parker Divisional Profile
The Division of Medical Biochemistry is a preclinical, basic science division in the UCT Faculty of Health Sciences. Our principal functions are teaching and research.
Undergraduate teaching is in medical biochemistry to MBChB students. Postgraduate teaching includes a vigorous Honours course (within the School of Biomedical Sciences) and MSc and PhD programmes. Our research activities fall into 5 major areas: (1) Regulation of collagen gene expression; (2) proteolytic processing of membrane proteins; (3) cellular and molecular biology of breast and oesophageal cancer; (4) endocytic processing with particular emphasis on mechanisms for intracellular survival of mycobacteria; (5) molecular reproductive endocrinology. The Division also houses the Oesophageal Cancer Research Group funded by the MRC. The Group includes researchers from UCT, UNITRA, Stellenbosch and the MRC with Professor Parker as the Director. Professor Parker continues to run the U.N.E.S.C.O. Molecular and Cell Biology Network laboratory, which allows access of UNESCO funds for training of scientists from developing countries. Professor Thilo has ongoing collaborations on mycobacterial research with groups in France and Germany. A/Professor Arieh Katz and Dr Colleen Flanagan are co-directors of the MRC/UCT Research Group for Receptor Biology and still has a very active collaboration with Professor Millar who is currently Director of the MRC Reproductive Biology Unit in the United Kingdom. The Division also regularly hosts researchers from other developing countries for training in specialised techniques. Divisional Statistics Permanent and Long-term Contract Staff
Professors Total 20
Honorary Students
Doctoral
Undergraduate 374 Total 398
Research Fields and Staff Permanent Staff
Professor M. Iqbal Parker Head of Division and Director Research Operations; cel ular and molecular biology breast and oesophageal cancer; collagen gene regulation A/Professor Lutz Thilo endocytic and membrane trafficking; mycobacterial phagosomes A/Professor Arieh Katz molecular reproductive endocrinology Dr Cynthia Sikakana Senior Lecturer; drug and xenobiotic metabolism Dr Denver Hendricks Senior Lecturer; oesophageal and cervical cancer Dr Edward Sturrock Wel come Trust Senior Fellow; structure/function studies on angiotensin-converting enzymes Honorary Staff
Professor R.P. Millar Honorary Professor – Director of MRC Reproductive Biology Unit, Edinburgh Dr Edward Sturrock Honorary Senior Lecturer; structure/function studies on angiotensin-converting enzymes Dr Colleen Flanagan Honorary Senior Lecturer; G protein – coupled receptors Dr Henry Jabbour Honorary Senior Lecturer; Cyclooxygenases in cancer Scientific Officers
Dr Tommy Haylett Research Officer; endocytic processing
Sylva Schwager Senior Scientific Officer; proteolytic processing of membrane proteins Postdoctoral Fellows
Dr Bo Wang Identification of genes involved in susceptibility to oesophageal cancer Dr Bernhard J. Fromme Interaction of HIV-1 subtype C gp120 with LCRS chemokine receptor Dr Sharon Prince The role of TBX2 in the cell cycle and cancer Dr Collet Dandara Genetic polymorphisms in oesophageal cancer Dr Virna Leaner Regulation of collagen gene expression Dr Trudie van Rensburg Expression of hypoglycosylated angiotensin converting enzyme Dr Anne Smith Synthesis of 3-prolyl substituted lisinopryl inhibitors Dr Aloysius Nchinda The computer modelling and synthesis of C-domain selective ACE inhibitors Dr Shaun Cochrane Internalisation of the type 2 GNRH Receptor Divisional Contact Details
Postal Address: Division of Medical Biochemistry, University of Cape Town, Faculty of
Health Sciences, Anzio Road, Observatory, 7925
CLINICAL LABORATORY SCIENCES DIVISION OF MEDICAL MICROBIOLOGY Head of Division: Professor Lafras M. Steyn Divisional Profile Members of the division of Medical Microbiology continue to provide diagnostic services, undergraduate and postgraduate medical student training, conduct research and provide training for science students interested in a research career. The composition of the Division is complex with staff drawn from the University of Cape Town, Groote Schuur Hospital and Red Cross Children’s Hospital and National Health Laboratory Service (NHLS). The microbiology diagnostic laboratories are located at the two hospitals, while the molecular research laboratories are located in the Institute of Infectious Diseases Building, Wernher Beit South, Health Sciences Campus. Aside from providing a full range of diagnostic services, the division is involved in clinical and diagnostic trials, investigating outbreaks of infection, and in defining the epidemiology of various infectious agents. Important areas of research focus on tuberculosis, bacterial antibiotic resistance, campylobacter infections and nosocomial pathogenes. A major effort is directed into developing novel vaccines and vaccine vectors. The division also has a highly cited site on the World Wide Web. Divisional Statistics
Permanent and Long-term Contract Staff
Professors 1 Associate Professors
Honorary Staff Honorary Lecturers
Students
Postdoctoral 4 Registrars 2 Doctoral 4 Masters 3 Honours 10 Undergraduate 180 Total 203
Research Fields and Staff
Permanent Staff Professor Lafras M. Steyn molecular biology of mycobacterium tuberculosis Dr Gay Elisha antibiotic resistance mechanisms and molecular epidemiology Dr Steve Oliver infection control policies and antibiotic usage Dr Andrew Whitelaw development of new diagnostic assays for tuberculosis Registrars, Joint Appointments
Dr Sumaya Haffejee Dr Colleen Bamford Honorary Staff Dr H. Hoppe Protozoan parasites Associate Professor Albert Lastovica Campylobacter and Helicobacter
Dr Linda Gail Bekker Immunopathogenesis of tuberculosis
Dr Marc Mendelson Innate immune response to mycobacterium tuberculosis Contract Research Staff
Dr Jenny Ramesar Human papillomavirus typing Dr Mark Nicol Phenotypic and genotypic characterisation of clinical strains in Mycobacterium tuberculosis causing pulmonary and extra-pulmonary disease in children Heidi Segal Carbapenen resistance in Pseudomonas aeruginosa
Postdoctoral Fellows Dr Ros Chapman mycobacterial stress responses Dr Karen Shires coldshock in mycobacteria Dr Gavin Rush attenuation of gene expression in mycobacteria Dr Lemese Ah Tow development of novel diagnostic methods for tuberculosis Divisional Contact Details Postal Address: Division of Medical Microbiology, University of Cape Town, Medical School, Anzio Road, Observatory, 7925 Telephone: SA (21) 406 6363 Fax: SA (21) 448 8153 E-mail: [email protected]
Webpage: http://www.uct.ac.za/depts/mmi/index.html
CLINICAL LABORATORY SCIENCES DIVISION OF MEDICAL VIROLOGY Head of Division: Professor Girish J. Kotwal Divisional Profile
The Division of Medical Virology consists of three major research groups, namely, Viral vaccines group, HIV diversity and pathogenesis group and the viral biotechnology group. In mid-2004, the research groups after several decades in the basement and in the Wernher and Beit North have moved to the newly renovated Wernher and Beit South top floor. The clinical virology which was located in Wernher and Beit North for decades moved to the Groote Schuur Hospital under the NHLS umbrella. During 2004, Associate Professor Annalise Williamson was promoted to Professor. All the three research groups continue to receive funding from several different sources including SAAVI, DST Innovation Fund, CIPRA, Wellcome Trust, Doris Duke etc. In addition, the Division received funding for the purchase of a major piece of equipment to perform protein interaction studies. Members of the Division have been very active in the IIDMM administration, serving on the membership committee, the research committee, the finance committee and the DMAG. Members of the division were also active in organising conferences at the Wolfson Pavilion, namely “Introduction of new vaccines into the Expanded program on Immunization (EPI) in Southern Africa: public health, educational, and economical aspects”, the first international conference on natural products and molecular therapy. Divisional Statistics
Permanent and Long-term Contract Staff Professors 2 Associate Professors
Lecturers 1 Research and Technical Support Staff
Total 52 Honorary Staff
Honorary Lecturers
Students
Postdoctoral 9 Masters 7 Doctoral 13 Total 29
Research Fields and Staff Permanent Staff Professor Girish J. Kotwal viral evasion of host defense; drug discovery Professor Anna-Lise Williamson Human Papillomaviruses; HIV-1 vaccine development Associate Professor Carolyn Williamson HIV molecular biology; HIV-1 vaccine development Dr Diana Hardie molecular biology of Hepatitis B Virus - management of diagnostics viral lab Dr Jane Yates management of diagnostic virology laboratories; Parvovirus B19, viral infections in the immunocompromised Dr Diane Marais Human Papillomavirus Immunology Dr Heidi Smuts Hepatitis C; Novel viruses (TT virus, human metapneumovirus); infectious agents in oesophageal cancer Lecturers Dr Jo-Ann Passmore Registrars, Joint Appointments
Dr Marvin Hsiao molecular diagnostics Dr Craig Corcoran molecular diagnostics
Honorary Staff
Dr Tim Tucker Senior Lecturer; HIV vaccine development Dr Wolfe Katz vaccine development
Contract Research Staff
Mr. Bruce Allan diagnosis of human papillomavirus Dr William Bourn HIV Vaccines Mrs. Helba Bredell HIV Mrs. Debbie de Villiers Human Papillomavirus Mr. Jandre Grobler HIV Mr. Rodney Lucas HPV Vaccines Mr. Baraka (Lucky) Malaza HIV Ms Marleze Rheeder HIV Vaccines Ms Yolanda Truter HIV Vaccines Mrs. Tracey Mul er HIV Mr. Craig Adams HIV Vaccines; HIV Diversity Ms Florette Treunicht Acute infection with HIV-1 subtype C study (CAPRISA) Dr Joanne van Harmelen HIV vaccine development (SAAVI); HIV diversity (CAPRISA) Distinguished Visitors
Dr Mary Phillips (Wellcome Trust - UK) Dr Wolfgang Preiser (University of Frankfurt) Dr Barry Rouse (University of Tennessee) Dr Gary Cohen (University of Pennsylvania) Postdoctoral Fellows Dr Wendy Burgers HIV Vaccines
Dr Vandana Govan HPV Dr Darren Marten HIV Recombination Dr Helen Stutz HIV BCG Vaccines (SAAVI) Dr Mbulelo Maneli HIV Diversity Dr Makobetsa Khati Aptamers Divisional Contact Details Postal Address: Division of Medical Virology, Wernher and Beit Building South Wing, University of Cape Town, Medical School, Anzio Road, 7925 Telephone: SA (21) 406 6126 Fax: SA (21) 406 6018 Webpage: http://www.uct.ac.za/depts/mmi/index.html CLINICAL LABORATORY SCIENCES
Research Output
(Including the following Divisions/Institutes: Chemical Pathology (including the Chemical Pathology sections of Groote Schuur Hospital and Red Cross War Memorial Children’s Hospital), Forensic Medicine and Toxicology (including the Gender, Health and Justice Research Unit), Haematology, Human Genetics (including the MRC/UCT Human Genetics Research Unit and the CANSA Colorectal Cancer Research Consortium), Immunology (including the MRC/UCT Immunology of Infectious Diseases Unit), Medical Biochemistry (including the MRC/UCT Oesophageal Cancer Research Group and the MRC/UCT Research Group for Receptor Biology) Medical Microbiology and Medical Virology) ARTICLES IN PEER-REVIEWED JOURNALS
Artz, L. 2004. Better safe than sorry: Magistrates’ views on the Domestic Violence Act. South African Crime Quarterly, 7: 1-8. Artz, L. 2004. Tough choices: Difficulties facing magistrates in applying protection orders. South African Crime Quarterly, 8: 25-30. Berman, M.C. and Karlish, S.J. 2003. Interaction of an aromatic dibromoisothiouronium derivative with the Ca2+- ATPase of skeletal muscle sarcoplasmic reticulum. Biochemistry, 42: 3556-3566. Billings, B., Smith, S.A., Zhang, Z., Lahiri, D.K. and Kotwal, G.J. 2004. Lack of N1L gene expression results in a significant decrease of vaccinia virus replication in mouse brain. Annals of New York Academy of Science, 1030: 297-302. Brombacher, F. 2004. Anti IL - 12 auto - vaccination: A treatment for experimental autoimmune encephalomyelitis at the expense of reduced cell - mediated immunity. Journal of Immunology, 34: 3572-3581. Brombacher, F. 2004. IL - 4 confers protection against the early acute phase of Cryptosporidium parvum infection by promoting Th 1 cytokine expression. Journal of Infectious Diseases, 190: 1019-1025. Brombacher, F. 2004. IL-4/IL-13-activated alternative macrophages are essential to survive schistosomiasis and downmodulate Type 1 responses and immunopathology. Immunity, 20: 623-635. Brombacher, F. 2004. Intestinal pathology during acute toxoplasmosis is IL - 4 dependent and unrelated to parasite burden. Parasite Immunology, 26: 75-82. Brombacher, F. 2004. Mice deficient in interleukin-4 (IL-4) or IL-4 receptor alpha have higher resistance to sporozoite infection with plasmodium berghei (ANKA) than do naive wild-type mice. Infection and Immunity, 72(1): 322-331. Brombacher, F. 2004. P75 Tumor necrosis factor-receptor shedding occurs as a protective host response during African Trypanosomiasis. Journal of Infectious Diseases, 189: 527- 539. Brombacher, F. 2004. Pinpointing IL-4-independent and IL-4-influenced acquisition and maintenance if Th2 activity by CD4 T cells. European Journal of Immunology, 34: 686-694.
Brombacher, F. 2004. Role of IL-4-induced GATA-3 expression as a time-dependent instruction switch on cytokine expression in helper T cell differentiation. Journal of Immunology, 174: 6158-6166. Chubb, A., Schwager, S.L.U., Van der Merwe, E.L., Ehlers, M.R.W. and Sturrock, E.D. 2004. Deletion of the cytoplasmic domain increases basal shedding of angiotensin-converting enzyme. Biochemical and Biophysical Research Communications, 314: 971-975. Davies, J.Q., Hall, P., Kaschula, R.O.C., Sinclair-Smith, C.C., Hartley, P.S., Rode, H. and Millar, A.J.W. 2004. Hepatoblastoma - Evolution of management and outcome and significance of histology of the resected tumor. A 31-year experience with 40 cases. Journal of Pediatric Surgery, 39(9): 1321-1327. DiPerna, G., Stack, J., Bowie, A.G., Boyd, A., Kotwal, G.J., Zhang, Z., Arvikar, N.K., Latz, E., Fitzgerald, K.A. and Marshall, W.L. 2004. Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signalling by toll-like receptors. Journal of Biological Chemistry, 279(35): 36570-36578. Ganesh, V.K., Smith, S.A., Kotwal, G.J. and Murthy, K.H. 2004. Structure of vaccinia complement protein in complex with heparin and potential implications for complement regulation. Proceedings of the National Academy of Sciences of the United States of America, 101(24): 8924-8929. Gordon, K., Redelinghuys, P., Schwager, S.L.U., Ehlers, M.R.W., Papageorgio, A.C., Natesh, R., Acharya, K.R. and Sturrock, E.D. 2003. Deglycosylation, processing and crystallization of human testis angiotensin converting enzyme. Biochemical Journal, 371: 437-442. Govender, D., Ramdial, P.K., Clark, B. and Chetty, R. 2004. Clear cell (glycogen-rich) gastric adenocarcinoma. Annals of Diagnostic Pathology, 8(2): 69-73. Govender, D., Sing, Y. and Chetty, R. 2004. Sertoli cel s nodules in the undescended testis: A histochemical, immunochistochemical, and ultrastructural study of hyaline deposits. Journal of Clinical Pathology, 57(2): 802-806. Grobler, J., Gray, C.M., Rademeyer, C., Seoighe, C., Ramjee, G., Karim, S.A., Morris, L. and Williamson, C. 2004. Incidence of HIV-1 dual infection and its association with increased viral load set point in a cohort of HIV-1 subtype C-infected female sex workers. Journal of Infectious Diseases, 190(7): 1355-1359. Hadley, G.P., Govender, D. and Landers, G. 2004. Primary tumours of the liver in children: An African perspective. Pediatric Surgery International, 20: 314-318. Hammersma, H., Gardner, J. and Beighton, P. 2003. The natural history of sclerosteosis. Clinical Genetics, 63: 191-196. Hassan, H., Toerien, A. and Potter, P.C. 2003. Evaluation of immunotherapy for seasonal and perennial allergic rhinitis. Current Allergy and Clinical Immunology, 16(11): 22-23. Heath, L.E., Martin, D., Warburton, L., Perrin, M., Horsfield, W., Kingsley, C., Rybicki, E.P. and Williamson, A.-L. 2004. Evidence of unique genotypes of Beak and Feather Disease Virus in southern Africa. Journal of Virology, 78(17): 9277-9284.
Hesseling, P.B., Harley, E.H., Zietsman, L., Van Lill, S., Preston-Martin, S. and Wessels, G. 2004. Incidence of acute lymphoblastic leukaemia in white and coloured children in the Western Cape. South African Medical Journal, 94(7): 533-536. Ho, V.C., Gupta, A., Kaufmann, R. Todd, G., Vanaclocha, F., Takaoka, R., Fölster-Holst, R., Potter, P., Marshall, K., Thurston, M., Bush, C. and Cherill, R. 2003. Safety and efficacy of nonsteroid pimecrolimus cream 1% in the treatment of atopic dermatitis in infants. Journal of Pediatrics, 142: 155-162. Jaffray, A., Shephard, E.G., Van Harmelen, J., Williamson, C., Williamson, A.-L. and Rybicki, E.P. 2004. Human immunodeficiency virus type 1 subtype C Gag virus-like particle boost substantially improves the immune response to a subtype C gag DNA vaccine in mice. Journal of General Virology, 85(2): 409-413. Jeebhay, M., Robin, T.G. and Lopata, A.L. 2004. World at work: Fish processing workers. Occupational and Environmental Medicine, 61(5): 471-474. Lastovica, A.J. 2003. Molecular typing of Campylobacter jejuni and Campylobacter coli. Journal of Clinical Microbiology, 41(3): 1349-1350. Lastovica, A.J. 2003. Optimal detection of Campylobacter spp in stools. American Journal of Clinical Pathology, 56: 480. Lastovica, A.J. 2003. Prevalence and optimal detection of C.upsaliensis in stool specimens. Clinical Infectious Diseases, 36: 1624-1625. Lastovica, A.J. and Le Roux, I.M. 2003. Serious Thrombocytopenia due to Dengue Hemorrhagic fever treated with high dosages of immunoglobulin. Clinical Infectious Diseases, 36(June): 1623. Lemmer, E.R., Vessey, D., Gelderblom, W.C.A., Shephard, E.G., Van Schalkwyk, D.J., Van Wijk, R.A., Marasas, W.F.O., Kirsch, R.E. and Hall, P. 2004. Fumonisin B1-induced hepatocellular and cholangiocellular tumors in male Fischer 344 rats: Potentiating effects of 2-acetylaminofluorene on oval cell proliferation and neoplastic development in a discontinued feeding study. Carcinogenesis, 25(7): 1257-1264. Lopata, A.L. 2004. Adverse reactions to fish. Current Allergy and Clinical Immunology, 17: 4-8. Lopata, A.L. 2004. Evaluating allergic responses to bird allergens. Current Allergy and Clinical Immunology, 17(2): 87-90. Lopata, A.L. 2004. Qualitative and quantitative evaluation of bird specific IgG antibodies. International Archives of Allergy and Immunology, 134(2): 173-178. Lopata, A.L., Jeebhay, M., Baatjies, R. and Thrower, S.J. 2004. Occupational allergies in the seafood industry - a comparative study of Australian and South African workplaces. International Maritime Health, 55(4): 61-72. Lopata, A.L., Schinkel, M., Potter, P.C., Jeebhay, M., Hashemi, C., Johansson, S.G.O. and Van Hage-Hamsten, M. 2004. Qualitative and quantitative evaluation of bird specific IgG antibodies. International Archives of Allergy and Applied Immunology, 134: 173-178. Loveland, B.E., Williams, L., Baker, L., Brandon, M.R., Xing, P.X., Kahn, D., McKenzie, I.F.C., Milland, J., Kyriakou, P., Thorley, B.R., Christiansen, D., Lanteri, M.B., Van
Regensburg, M., Duffield, M. and French, A.J. 2004. Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons. Xenotransplantation, 11: 171-183. Mall, A.S. and Taylor, K.L. 2004. The relationship of a Helicobacter Heilmanii infection to the mucosal changes in abattoir and laboratory pig stomach. Surgery Today, 34: 943-949. Mangisa, N.P., Kew, M.C., Smuts, H., Kramvis, A., Linley, W., Skelton, M., Tucker, T., Hall, P., Kahn, D. and Jilbert, A.R. 2004. Molecular characterisation of duck hepatitis B virus isolates from South African ducks. Virus Genes, 28(2): 179-186. McIntosh, D.B., Clausen, J.D., Vilsen, B., Einholm, P. and Andersen, J.P. 2004. Glutamate-183 in the conserved TGES motif of domain A of sarcoplasmic reticulum Ca2+-ATPase assists in catalysis of E2/E2P partial reactions. Biochemistry, 101(9): 2776-2781. Morgan, K., Conklin, D., Pawson, A.J., Sellar, R., Ott, T.R. and Millar, R.P. 2003. A transcriptionally active human typeII Gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12. Endocrinology, 144(2): 423-436. Morganroth, J., Potter, P.C. and Taglietela, M. 2003. Consensus group on new generation antihistamines (CONGA). S.T. Holgate: Panel of cardiotoxity. Clinical Experimental Allergy, 33: 1305-1324. Mossmann, H., Claussen, B., Fvrster, I., Brombacher, F., Holscher, C., Mohrs, M., Arendse, B., Schwegmann, A.R., Radvanska, M.B., Kirsch, R. and Hall, P. 2004. Alternative macrophage activation is essential for survival during Schistosomiasis and downmodulates T Helper 1 responses and immunopathology. Immunity, 20: 623-635. Novitzky, N., Thomas, V., Abrahams, L., Du Toit, C.E. and McDonald, A.B. 2004. Increasing dose intensity of Anthracycline antibiotics improves outcome in patients with acute Myelogenous Leukemia. American Journal of Hematology, 76(4): 319-329. Novitzky, N., Thomas, V., Hale, G. and Waldmann, H. 2004. CAMPATH-1 Antibodies "In the Bag" for haematological malignancies: The Cape Town experience. Cytotherapy, 6(2): 172-181. Novitzky, N., Thomas, V., Stubbings, H., Hale, G. and Waldmann, H. 2004. Radiotherapy-based conditioning is effective immunosuppression for patients undergoing transplantation with T-cell depleted stem cell grafts for severe aplasia. Cytotherapy, 6(5): 450-456. Nuttall, J., Wilmshurst, J., Ndondo, A., Yeats, J., Corcoran, C., Hussey, G.D. and Eley, B.S. 2004. Progressive multifocal leukoencephalopathy after initiation of highly active antiretroviral therapy in a child with advanced human immunodeficiency virus infection: A case of immune reconstitution inflammatory syndrome. The Pediatric Infectious Disease Journal, 23(7): 683-685. Orren, A. and Potter, P.C. 2004. Complement component C6 deficiency and susceptibility to Neisseria Meningitidis infection. South African Medical Journal, 95(5): 345-346. Papp, K., Staub, D., Harper, J., Potter, P.C., Puig, L., Ortonne, J.P., Molloy, S., Barbier, N. and Paul, C. 2004. Effect of Pimecrolimus Cream 1% on the long-term course of paediatric atopic dermatitis. International Journal of Dermatology, 43(12): 978-983.
Patel, M., Andronikou, S., Solomons, R., Sinclair, P. and McCulloch, M. 2004. Idiopathic arterial calcification in childhood. Pediatric Radiology, 34: 652-655. Pawson, A.J., Maudsley, S.R., Lopes, J., Katz, A.A., Sun, Y.M., Davidson, J.S. and Millar, R.P. 2003. Multiple determinants for rapid agonist-induced internalization of a nonmammalian gonadotropin-releasing hormone receptor: A putative palmitoylation site and threonine doublet within the carboxyl-terminal tail are critical. Endocrinology, 144(9): 3860-3871. Pillay, K., Solomons, R., Daubenton, J.D. and Sinclair-Smith, C.C. 2004. Interdigitating dendritic cell sarcoma: A report of four paediatric cases and review of the literature. Histopathology, 44(3): 283-291. Pillay, N.S., Kellaway, L.A. and Kotwal, G.J. 2004. Molecular mechanisms, emerging etiological insights and models to test potential therapeutic interventions in Alzheimer's disease. Current Alzheimer Research, 1: 295-306. Post, F.A. and Steyn, L.M. 2004. Genetic polymorphism in Mycobacterium tuberculosis isolates from patients with chronic multidrug-resistant tuberculosis. Journal of Infectious Diseases, 190: 99-106. Potter, P.C. 2003. Levocetirizine is effective for symptom relief including nasal congestion in adolescent and adult (PAR) sensitized to house dust mites. Allergy, 58: 893-899. Potter, P.C. 2003. The increase in prevalence of asthma and atopy in Africans. Asthma Acta, 4: 57-58. Potter, P.C., Van Niekerk, C.H. and Scheepers, J.M. 2003. Fexofenadine does not impair reaction time, decision making and driver behaviour. Annals of Allergy, 91: 177-181. Potter, P.C., Van Niekerk, C. and Schoeman, H.S. 2003. Triamcinolone Acetonide (Nasacor AQ) improves quality of life in persistent allergic rhinitis. Annals of Allergy, 91(4): 368-374. Rademeyer, C., Van Harmelen, J.H., Ramjee, G., Karim, S.S. and Williamson, C. 2004. Heterosexual transmission of multiple highly conserved viral variants in HIV-1 subtype C-infected seronegative women. AIDS, 18(15): 2096-2098. Rajput, J., Moss, J.R., Hutton, A.T., Hendricks, D.T., Arendse, C.E. and Imrie, C. 2004. Synthesis, characterization and cytotoxicity of some palladium(II), platinum(II), rhodium(I) and iridium(I) complexes of ferrocenylpyridine and related ligands. Crystal and molecular structure of trans-dichlorobis (3-ferrocenylpyridine) palladium(II). Journal of Organometallic Chemistry, 689: 1553-1568. Ramburan, R.M., Chetty, R., Hadley, G.P., Naidoo, R. and Govender, D. 2004. Microsatellite analysis of the DCC gene in nephroblastoma: Pathologic correlations and prognostic implications. Modern Pathology, 17: 89-95. Rebello, M.T., Bonapace, G., Waheed, A., Shah, G.N., Sly, S., Ramesar, R., Vorster, A.A., Roberts, L.J., Ehrenreich, L.S., Oppon, E., Gama, A.D., Bardien, S. and Greenberg, L.J.H.L. 2004. Apoptosis-inducing signal sequence mutation in carbonic anhydrase IV identified in patients with the RP17 form of retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences, 101: 6617-6622. Ronacher, K., Matsiliza, N., Nkwanyana, N., Pawson, A.J., Adam, T., Flanagan, C.A., Millar, R. and Katz, A.A. 2004. Serine residues 338 and 339 in the carboxyl-terminal tail of the type
II gonadotropin-releasing hormone receptor are critical for ß-arrestin-independent internalization. Endocrinology, 145(10): 4480-4488. Rousseau, J., Pokorny, L., Glaser, J. and Creemers, P.C. 2003. Presisposing and protective HLA-DR and DQ al eles for rheumatoid arthritis in South African mixed-ancestry and Xhosa populations. South African Journal of Science, 99: 89-92. Rousseau, J., Williams, R.C. and Creemers, P.C. 2003. HLA DRB1, DQA1, DQB1 and DPB1 polymorphisms in Namibian Khoi and San and in the Xhosa and South African mixed-ancestry population. South African Journal of Science, 99: 81 - 89. Rush, G. and Steyn, L.M. 2004. Translation enhancement by optimized downstream box sequences in Escherichia coli and Mycobacterium smegmatis. Biotechnology Letters, 27(3): 173-179. Ryffel, B. 2004. Arthropod-derived histamine-binding protein prevents murine allergic asthma. Journal of Immunology, 173(5): 3281-3286. Ryffel, B. 2004. Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88. Journal of Clinical Investigation, 114(12): 1790-1799. Ryffel, B. 2004. Reduced local growth and spread but preserved pathogenicity of a{Delta}purC mycobacterium tuberculosis auxotrophic mutant in gamma interferon receptor-deficient mice after aerosol infection. Infection and Immunity, 73(1): 666-670. Ryffel, B. 2004. Toll-like receptor pathways in the immune responses to mycobacteria. Microbes and Infection, 6(10): 946-959. Ryffel, B. and Botha, T. 2003. Reactivation of latent tuberculosis infection in TNF-deficient mice. Journal of Immunology, 171(6): 3110-3118. Sabaratnam, R.M., Govender, D. and Reddi, A. 2004. Acinic cell carcinoma: An unusual cause of Bronchial obstruction in a child. Pediatric and Developmental Pathology, 7: 521-526. Segal, H., Elisha, B.G. and Nelson, E.C. 2004. Genetic environment and transcription of ampC in an Acinetobacter baumannii clinical isolate. Antimicrobial Agents and Chemotherapy, 48(2): 612-614. September, A., Vorster, A.A., Ramesar, R. and Greenberg, L.J.H.L. 2004. Mutation spectrum and founder chromosomes for the ABCA4 gene in South African Stargard Disease patients. Investigative Ophthalmology and Visual Science, 1(45): 1705-11. Smythe, D. 2004. Missed opportunities: Confiscation of weapons in domestic violence cases. South African Crime Quarterly, 10: 19-26. Snyman, J.R., Potter, P.C. and Levin, J. 2004. The effect of betamethazone and loratadine combination therapy on severe exacerbations of allergic rhinitis: A randomised controlled trial. Clinical Pharmacology. Clinical Drug Investigation, 24(5): 265-273. Steenkamp, D.J. and Vogt, R. 2004. Preparation and utilization of a reagent for the isolation and purification of low-molecular-mass thiols. Analytical Biochemistry, 325: 21-27.
Steinman, H., Dawson, H., Kawalski, M., Toerien, M. and Potter, P.C. 2003. Bronchial hyperresponsiveness and atopy in urban and rural South African children. Paediatric Allergy and Clinical Immunology, 14: 383-393. Van Zyl-Smit, R., Firth, J.C., Duffield, M. and Marais, A.D. 2004. Renal tubular toxicity of HMG-CoA reductase inhibitors. Nephrology Dialysis Transplantation, 19: 3176-3179. Wahn, U., Metlzer, E.O., Finn, A., Kowalski, M.L., De Costa, P., Hedlin, G., Bachert, C., Pinto, R., Bregna Cagnami, C., Potter, P.C., Simons, F.E.R. and Runtin, E. 2003. Fexofenadine is efficacious and safe in children with seasonal allergic rhinitis. Journal of Allergy and Clinical Immunology, 111: 763-769. CHAPTERS IN BOOKS
Potter, P.C. 2003. Allergen immunotherapy. MIMS Disease Review: 1-5. Pinegowrie: MIMS. Potter, P.C. 2003. An approach to rhinitis including allergic rhinitis. MIMS Disease Review: 27-35. Pinegowrie: MIMS. Smythe, D. and Parenzee, P. 2004. Acting against domestic violence. In B. Dixon and E. van der Spuy (Eds.), Justice gained? Crime and crime control in South Africa’s transition: 140- 162. Cape Town: University of Cape Town Press, Willan Publishers. PEER-REVIEWED PUBLISHED CONFERENCE PROCEEDINGS Masters, K. and Duffield, M. 2004. WebCT and Anatomical Pathology tutorials. Proceedings of the 4th IEEE International Conference of Advanced Learning Technologies (ICALT2004), Joensuu, Finland, 30 August - 1 September 2004, 1039-1043. Rebello, M.T., Bonapace, G., Waheed, A., Shah, G.N., Sly, S., Ramesar, R., Vorster, A.A., Roberts, L.J., Ehrenreich, L.S., Oppon, E., Gama, A.D., Bardien, S. and Greenberg, L.J.H.L. 2004. An apoptosis-inducing signal sequence mutation suggests carbonic anhydrase IV underlies the RP17 form of autosomal dominent retinitis pigmentosa. Proceedings of the XI International Symposium on Retinal Degeneration, Australia, 6617-6622. NON PEER-REVIEWED PUBLISHED CONFERENCE PROCEEDINGS
Mabizela, N., Rodgers, A., Sturrock, E.D. and Schwager, S.L. 2004. Analysis of urinary bikunin in calcium oxalate crystals from the black and white population groups in South Africa. Proceedings of 10th International Symposium on Urolithiasis. Kidney Stones: Inside and Out, Hong Kong, 85-86. Novitzky, N., Thomas, V., Stubbings, H., Hale, G. and Waldmann, H. 2004. Radiotherapy-based conditioning is effective immunosuppression for patients undergoing transplantation with T-cell depleted stem cell grafts for severe aplasia. Proceedings of 44th Annual Conference of the Federation of South African Societies of Pathology (FSASP), Stellenbosch University Campus, Cape Town, 92.
PUBLISHED CONFERENCE ABSTRACTS
Clarkson, V., Hall, P., Shephard, E.G., Kirsch, R. and Marais, A.D. 2004. The ethanol feeding increases CYP2E1 activity in the methionine-choline-deficient mouse model for NASH. Liver International 2004 24: Supplement 4: 20. Clarkson, V., Shephard, E.G., Kirsch, R., Marais, A.D. and Hall, P. 2004. Lipid peroxidation is increased following endotoxin challenge in a rodent nutritional model of NASH. Liver International 2004 24: Supplement 4: 20. Craig, P. 2003. Training of parent support groups in basic counselling skills and genetic knowledge. 10th Biennial Congress of the Southern African Society of Human Genetics: 33- 34. Epstein, D., Locketz, M.L., Watermeyer, G. and Hall, P. 2004. The aetiology of oesophageal ulceration in HIV infected patients in Cape Town, South Africa. South African Medical Journal, 94(8): 686. Fenemore, B., Lopata, A. and Potter, P.C. 2003. Evaluation of the Western Blot in allergy testing. Current Allergy and Clinical Immunology, 16(3): 118. Hall, P. 2004. A pilot study to evaluate the role of serum lipids and LDL particle size as in disease severity in subjects with NAFALD. South African Medical Journal, 94(8): 682. Hall, P. 2004. Correlation of body mass index (MBI) with the different types of non-alcoholic fatty liver disease (NAFALD). South African Medical Journal, 94(8): 682. Hall, P. 2004. Drug induced hepatitis (including herbs). Pathology International 2004 54(Suppl): 295-298. Hall, P. 2004. Histological findings on liver biopsy in South African patients with non- alcoholic fatty liver disease. South African Medical Journal, 94(8): 687. Hall, P. 2004. The correlation of serum ALT level and AST/ALT ratio and the histological types in patients with non-alcoholic fatty liver disease (NAFALD). South African Medical Journal, 94(8): 676. Hall, P., McLeod, H., Panieri, E., Elazzabi, T., Dent, D. and Mall, A.S. 2004. The expression of mucin in gastric remnant carcinoma. A histological and immunohistochemical study. South African Journal Surgery, 42:25. Hawarden, D., Mileham, J. and Potter, P.C. 2003. Anaphylaxis: Rather a shock. Current Allergy and Clinical Immunology, 16(3): 117. Jeebhay, M., Baatjies, R., Lopata, A.L., Bateman, E.D. and Robin, T.G. 2004. Baker's asthma in small bakeries of a supermarket chainstore in the Western Cape. SA Respiratory Journal, 10(2): 71. Jeebhay, M., Robins, T.G., Baatjies, R. and Lopata, A.L. 2004. Environmental exposure characterization of fish processing workers in South Africa. X-2004 Conference on Exposure Assessment in a changing environment. Tijdschrift voor toegepaste Arbowetenschap, S(02): 1.
Jeebhay, M., Robins, T.G., Baatjies, R. and Lopata, A.L. 2004. Relationship between in vivo and in vitro markers of IgE in relation to work-related allergic symptoms among seafood processing workers. Current Allergy and Clinical Immunology, 17(3): 138. Jeebhay, M., Robins, T.G., Baatjies, R. and Lopata, A.L. 2004. Relationship between in vivo and in vitro markers of IgE in relation to work-related allergic symptoms among seafood processing workers (abstract 1158). XXIII Congress of the European Academy of Allergology and Clinical Immunology, Amsterdam, June 2004 EAACI: Published on CD-Rom. Novitzky, N., Thomas, V., Davison, G.M., Thomson, J. and Abrahams, L. 2004. A different but cost-effective schedule for mobilization of CD34+ cells for transplantation. Bone Marrow Transplantation, 33(Suppl 1): S95. Novitzky, N., Thomas, V., Hale, G. and Waldmann, H. 2004. T-cell depletion of stem cell grafts with Campath-1H 'in the bag' followed by cyclosporin immunosuppression remains a cost effective strategy in transplantation. Bone Marrow Transplantation, 33(Suppl 1): S93. Nurse, B., Motala, C. and Potter, P.C. 2004. HDM-Stimulated IL13 Release in atopic asthmatic children with a high prevalence of Ascaris Infestation. Current Allergy and Clinical Immunology, 17(3): 138-139. Nurse, B., Motala, C. and Potter, P.C. 2003. Lymphocyte proliferation and IgE responses in atopic South African children with a high prevalence of Ascaris infestation. Current Allergy and Clinical Immunology, 16(3): 120. Obihara, C.C., Van Liu, S., Marais, B.J., Hesseling, A.C., Lawrence, K., Potter, P.C., Bateman, E., Gie, R., Kimpen, J. and Beyers, N. 2003. The association between atopy, asthma and tuberculin skin test in children living in an area with high prevalence of tuberculosis. Current Allergy and Clinical Immunology, 16(3): 134. Olarogun, J., Marais, D.J., Soule, S. and Van der Spuy, Z.M. 2004. Effects of weight loss on dyslipidaemia in polycystic ovary syndrome. 40th Congress of SEMDSA (Society for Endocrinology, Metabolism, and Diabetes of South Africa) in Durban: 29. Potter, P.C. 2003. The increase in the prevalence of asthma bronchial hyperreactivity and atopy in Africans. In R. Sepiashvili (Ed.), Asthma: from Genes to Clinical Management. St. Petersburg. International Proceedings and Diseases. Monduzzi 2003; 109-112. Potter, P.C., Lisanti, M., Groenewald, M., Portes, R. and Weinberg, E.G. 2004. Pollen aeroallergen sensitisation and efficacy of Fexofenadine in children from the Southern Hemisphere. Current Allergy and Clinical Immunology, 17(3): 139. Potter, C., Lisanti, M., Groenewald, M., Portes, R., Weinberg, E., Vucovich, P., Puterman, A., Baena-Cagnani, C., Hardy, P. and Ruuth, E. 2004. Pollen allergen sensitization and efficacy of Fexofenadine in children from the southern Hemisphere. Journal of Allergy and Clinical Immunology, 113(2): 5232. Prescott, R. and Potter, P.C. 2003. FACS Analysis: A potentially useful tool in Allergy diagnosis. Current Allergy and Clinical Immunology, 16(3): 118. Schinkel, M., Potter, P.C., Jeebhay, M., Hashemi, C., Johansson, S.G.O., Van Hage-Hamsten, M. and Lopata, A.L. 2004. A comparison of qualitative and quantitative evaluation of bird specific IgG anitibodies in exposed and non-exposed individuals (abstract 1193).
XXIII Congress of the European Academy of Allergology and Clinical Immunology, Amsterdam, June 2004 EAACI: Published on CD-Rom. Steinman, H., Donson, H., Kawalski, M., Toerien, A. and Potter, P.C. 2003. Bronchial hyperresponsiveness and atopy in urban, peri-urban and rural South African children. Current Allergy and Clinical Immunology, 16(3): 117. Steinman, H., Donson, H., Kawalski, M., Toerien, A. and Potter, P.C. 2003. Rising prevalence of bronchial hyperresponsiveness and atopy in urban and rural South African children. Asthma Acta, 4: 126-127. Steinman, H., Donson, H., Kawalski, M., Toerien, A. and Potter, P.C. 2003. The rising prevalence of bronchial hyperresponsiveness and atopy in urban and rural South African children. World Asthma Congress, St. Petersburg, Russia. Asthma Acta, 4: 126. Wessels, G., Hesseling, P.B., Rossouw, H.S., Wainwright, L., Poole, J., Stones, D. and Harley, E.H. 2004. Epidemiological features of childhood leukaemia and other cancers in South Africa. Pediatric Blood and Cancer, 43(4): 476/P.J.028. EXTENSION AND DEVELOPMENT WORK
Artz, L. 2004 Member of Council, Criminology (and Victimology) Society of South Africa. Artz, L. 2004. Editorial Board Member, Acta Criminologica. Artz, L. 2004. Chairperson, Centre for the Study of Violence and Mental Health, Faculty of Health Sciences, University of Cape Town. Artz, L. 2004. Board Member, Family Law Centre, Cape Town Artz, L. 2004. Gender Expert, [National] Alliance for Crime Prevention Co-Convenor, Department of Justice/Lower Court Management Committee Domestic Violence Act Working Group Artz, L. 2004. Research Supervisor for SWEAT (Sex Workers Education and Advocacy Taskforce) Artz, L., Smythe, D. and Leggett, T. 2004. Reflections on integrated rape case management. Pretoria: UNICEF, 1-102. Moult, K. 2004. Justice served? Exploring alternative mechanisms to address violence againstwomen. Pretoria: UNICEF, 1-91. The Problem of Attrition in Rape Cases, in News and Views for Magistrates (Cape Town: Law, Race and Gender Research Unit, Faculty of Law, University of Cape Town), 1. CONSULTANCY
Artz, L. 2004. Consultant to the Department of Justice on domestic violence courts and the drafting of magistrate’s guidelines for the implementation of Domestic Violence Act. Artz, L. 2004. Consultant to the Foundation for Human Rights and Social Surveys on a study
on the vulnerability of women in South Africa.
Artz, L. 2004. Consultant to the Child Justice Alliance on research design for monitoring the
implementation of the Child Justice Bill. Artz, L. and Moult, K. 2004. Guest Course Convenors for Specific Offences (CRJ 512H): Department of Criminal Justice, Faculty of Law, UCT. Artz, L. and Smythe, D. 2004. Consultants to the National Directorate of Public Prosecutions on sexual offences courts (attrition in rape cases). Artz, L. and Smythe, D. 2004. Submissions to the South African Law Reform Commission on Sexual Offences. Doolan, K., Artz, L. and Smythe, D. 2004. Course lecturers for Sexual Assault, Domestic Violence and the Law: Implications for Health Care Providers. Department of Obstetrics and Gynaecology. Convenor: Professor Lynette Denny. Maw, S. and Artz, L. 2004. Course lecturers for Understanding Gender. Department of Obstetrics and Gynaecology. Course Convenor: Professor Lynette Denny. Moult, K. 2004. Trainer and consultant to the Law, Race and Gender Research Unit on domestic violence and HIV. Smythe, D. and Artz, L. 2004. Consultants to the Open Society Foundation for review of women’s advice centres in the Eastern Cape and KwaZulu-Natal UNIVERSITY PUBLICATIONS AND WORKS OF A POPULAR NATURE
Artz, L. 2004. Guest Editorial: The Criminal Law (Sexual Offences) Amendment Bill. Journal of Child and Adolescent Mental Health, 16(1): v-vii. Kotwal, G.J. 2004. Review article. HIV treatment and eradication in South Africa. Journal of Royal Society of Medicine, 97(1):1-2. Kotwal, G.J. and Abrahams, M.R. 2004. Review article. Growing poxviruses and determining virus titer. Methods in Molecular Biology, 269:101-12. Potter, P.C. 2004. Sublingual allergy immunotherapy: Highly effective and safe in children with allergic rhinitis and asthma. Paediatric Review, 1(1): 26-31.
Kursföreståndare: Prof. Torbjörn Andersson Institutet förhandsavgörande – ett svenskt perspektiv Promemoria inom ramen för kursen Europaprocess 30 hp vid Uppsala Universitet Höstterminen 2007 Kursföreståndare: Prof. Torbjörn Andersson 1 Inledning 1.1 Bakgrund Svenska domstolar har alltsedan inträdet i den Europeiska gemenskapen varit mycket re- striktiva med a