Claimed Subject Matter
Plant cells containing a nucleic acid construct
comprising a germline-specific plant promoter
operatively associated with a site-specific recombinase coding sequence, where the genome comprises a transcriptionally active selectable marker flanked by two recombination target sites; where said site-specific recombinase coding sequence operatively associated with said germline-specific plant promoter is selective for said recombination target sites flanking said selectable marker; where said germline-specific plant promoter is selected from the LAT52 gene promoter from tomato, the LAT56 gene promoter from tomato, the LAT59 gene promoter from tomato, the pollen-specific promoter of the Brassica S locus glycoprotein gene, and the pollen-specific promoter of the NTP303 gene; and where said site-specific recombinase coding sequence encodes a recombinase selected from Cre recombinase, FLP recombinase, and the R gene product of Zygosaccharomyces, including method for production of recombinant alleles.
Platinum complexes that exhibit antitumor cell
A gene encoding a peptide where said peptide
comprises a first domain and a second domain,
where: (a) said first domain comprises a hormone
selected from gonadotropin-releasing hormone, lamprey lll luteinizing hormone releasing hormone (l-LHRH-lll), beta chain of luteinizing hormone (bLH), luteinizing hormone, chorionic gonadotropin, the beta subunit of chorionic gonadotropin, follicle stimulating hormone, melanocyte-stimulating hormone, somatostatin, and analogues of these hormones; and (b) said second domain comprises a lytic peptide, where said lytic peptide consists of from 10 to 39 amino acid residues, is basic, and will form an amphipathic alpha helix.
A substantially purified peptide of a promyostatin Se-Jin Lee et al.
An isolated synthetic peptide having a sequence
AKEYAAAAAAKAAAA, AAEYAAAAAAKAAAA, AAKYAEAAAAKAAAA, and EAKYAAAAAAKAAAA, where the synthetic peptide binds to an MHC class II protein with higher affinity than a control peptide CII 261-273 or HA 306-318.
A composite material, comprising: (i) a polymer,
(ii) a polymerizer, (iii) microparticles of a
protected activator for the polymerizer, and (iv) a plurality of capsules; where the polymerizer is in
the capsules and comprises DCPD, the polymer comprises epoxy, the protected activator for the polymerizer comprises a ROMP catalyst protected by a paraffin wax that is soluble in the polymerizer, the capsules have an aspect ratio of 1:1 to 1:1.5, and an average diameter of 30-300 μm, and the capsules comprise a polymer of urea and formaldehyde, including a method of making.
A method of treating bone loss comprising the
Mark I. Greene et The Trustees of the University of
step of administering to said patient an amount of al.
a TRANCE/RANK inhibitor effective to inhibit osteoclastogenesis and/or osteoclast function ((bis-phenyl) benzene derivatives).
pathogen-detection domain and at least one
effector domain, said chimeric molecule being one that is non-naturally-occurring in a cell, where said pathogen-detection domain comprises a double-stranded RNA binding domain and said effector domain comprises an apoptosis mediator domain isolated from Apaf-1, including an agent having at least one double-stranded RNA-interacting molecular structure and at least one apoptosis-effector mediating molecular structure, said agent being one that is non-naturally-occurring in a cell, where said one apoptosis-effector mediating molecular structure comprises an apoptosis mediator domain isolated from Apaf-1.
An isolated nucleic acid molecule encoding a
polypeptide that exhibits polyketide synthetase
activity in the biosynthesis of cryptophycin under appropriate conditions, including vectors and host cells.
A method of identifying a candidate compound
that modulates apoptosis comprising: contacting a al. sample comprising anaphase promoting complex subunit 1 (APC1) with a test compound, under conditions that allow the test compound to bind to APC1; evaluating binding of the test compound to APC1, and identifying the test compound as a candidate compound that modulates apoptosis if the test compound binds to APC1.
A set of matched luminescent dyes comprising at
least two different dyes which in use covalently
bind to proteins within an extract of proteins from at least two cell samples, where the dyes within said set: (a) have a matched net charge which will maintain the overall net charge of the proteins upon such covalent binding and matched ionic and pH characteristics whereby relative migration of a protein labeled with any one of said dyes is the same as relative migration of said protein labeled with another dye in said set; and (b) each emit luminescent light at a wavelength that is sufficiently different from the emitted luminescent light of remaining dyes in said set to provide a detectably different light signal from the light signal of said remaining dyes in said set.
A method for diagnosing a predisposition for
pregnancy failure, spontaneous abortion or
premature birth in a pregnant patient comprising:
(a) contacting a physiological fluid sample potentially comprising a cell membrane-associated complement regulatory protein (CRP) from the patient with an anti-CRP antibody to form a CRP-antibody complex, where the anti-CRP antibody binds CD55; (b) measuring the quantity of CRP-antibody complex in the physiological fluid, wherein a reduced quantity of CRP-antibody complex in the sample relative to a corresponding control is indicative for a predisposition for pregnancy failure, spontaneous abortion or premature birth in the patient.
A method of oligonucleotide-mediated targeted
sequence alteration of a nucleic acid comprising:
combining a target nucleic acid in the presence of cellular repair proteins with a sequence-altering targeting oligonucleotide; and either adding lambda beta protein additionally to said combination or first contacting cells having said cellular repair proteins with an HDAC inhibitor or hydroxyurea; where said oligonucleotide-mediated targeted sequence alteration is dependent upon a cellular DNA mismatch repair mechanism; where said oligonucleotide is a single-stranded oligonucleotide 17-121 nucleotides in length, said oligonucleotide having an internally unduplexed domain of at least 8 contiguous deoxyribonucleotides, where said oligonucleotide is fully complementary in sequence to the sequence of a first strand of the nucleic acid target, but for one or more
mismatches as between the sequences of said internally unduplexed deoxyribonucleotide domain and its complement on said target nucleic acid first strand, each of said mismatches positioned at least 8 nucleotides from said oligonucleotide's 5' and 3' terminal, and where said oligonucleotide has at least one terminal modification selected from the group consisting of: at least one terminal locked nucleic acid (LNA), at least one terminal 2'--O--Me base analog, at least one terminal phosphorothioate linkage, and at least three terminal phosphorothioate linkages.
A modified Mycobacterium tuberculosis strain
which lacks a functional lspA gene, including a method for identifying Mycobacterium tuberculosis genes whose deletion or inactivation reduces Mycobacterium tuberculosis proinflammatory stimulation of macrophages.
A method for inducing an immune response to
one or more influenza polypeptides in a subject comprising: administering to the subject a composition comprising (a) a nucleic acid molecule comprising a sequence encoding an influenza type hemagglutinin (HA) polypeptide of an H1 subtype or an antigenic fragment thereof, where the sequence is codon-optimized for expression in a mammalian cell; (b) a mammalian promoter operably linked to the nucleic acid molecule, where the promoter directs transcription of mRNA encoding the influenza polypeptide;
and (c) a mammalian polyadenylation signal operably linked to the nucleic acid molecule, where the composition is administered in an amount sufficient for the sequence to express the influenza polypeptide at a level sufficient to induce an immune response in the subject.
A method for treating metastatic melanoma in a
patient in need thereof, comprising administering
a therapeutically effective amount of a selective endothelin B receptor (ETB) antagonist to said patient, with the proviso that said method does not include gene therapy.
An isolated antagonist that inhibits angiogenesis,
Peter C. Brooks et University of California
tumor growth, or metastasis by modifying
protein-protein interactions between MMP-9 and a beta1-containing integrin, wherein the isolated antagonist comprises an antibody reagent which specifically hinds to a polypeptide comprising CysArgLeuArgSerGlyGluProGlnCys.
A method of treating a subject comprising: a)
Jane Homan et al. The Arizona Board of Regents on
providing (i) a protein biocide active against
Cryptosporidium parvum, where said protein
biocide is phospholipase A2; and (ii) a subject infected with Cryptosporidium parvum; and b) orally administering said protein biocide to said subject under conditions such that said protein biocide reduces the growth or replication of said Cryptosporidium parvum.
A method for diagnosing chronic rejection of a
Fady K. Baddoura The Research Foundation of State
transplanted heart in an individual comprising the
steps of: a) administering a radiolabeled MECA-
79 antibody into the vasculature of a transplanted heart; b) allowing sufficient time for the radiolabeled MECA-79 antibody to distribute in the transplanted heart; and c) obtaining a radiographic image distribution of the radiolabeled MECA-79 antibody in the transplanted heart to determine the presence or absence of radiolabeled MECA-79 antibody in the transplanted heart, wherein the presence of radiolabeled MECA-79 in the transplanted heart is indicative of chronic allograft rejection.
C U R R I C U L U M V I T A E INFORMAZIONI PERSONALI SEGALA MARCO DANIELE V. xxxxxxxxxxx MILANO 02xxxxxx 02xxxxxx CODICE FISCALE SGLMCD55C31E704U Data di nascita 31 MARZO 1955 LOVERE (BG) ESPERIENZA LAVORATIVA • Date (da – a) 2009 ad oggi • Nome e indirizzo dell’attuale datore Direzione Scientifica - Ufficio Formazione Permanete ed Aggi
Existing Chemical Substance ID: 92045–14–2 CAS No. 92045–14–2 EINECS Name Fuel oil, heavy, high–sulfur EINECS No. 295–396–7 Molecular Formula <no data> Substance Group 6A Dataset created by: EUROPEAN COMMISSION – European Chemicals Bureau This dossier is a compilation based on data reported by the European Chemicals Industry following ’Council Regul