Microsoft word - biographie_x_leverve_en.doc

Xavier Leverve’s biography

Born on October 7th, 1950
Deputy Director of the Circulation, metabolism and nutrition institute since April 2008
Degrees and qualifications
Doctor of Medicine, PhD in sciences, Hospital practitioner and university professor
Qualifications in practice: Internal medicine, intensive care, nutrition
Professional experience
Assistant Head of Clinic, intensive care unit, Grenoble university hospital Post-doctorat : Laboratory of Biochemistry, section of Medical Enzymology, University of Amsterdam (Prof Dr JM Tager) Biophysics laboratory assistant, Grenoble university hospital Professor of therapy/intensive care, Grenoble university hospital Appointment to the French National Universities Board (CNU) (44-04 Nutrition) Professor of nutrition, Grenoble university hospital Director of unit 884 Inserm/Joseph Fourier University on fundamental and applied bioenergetics Head of the Human nutrition department, French National Institute for Agricultural Research (INRA), Paris Election to the CNU (Chairman of sub-department 44-04 Nutrition) Scientific Director for Human nutrition and food safety, INRA, Paris
1980 First Thesis Prize, Grenoble University
2001 Honoris Causa Doctor, University of Bucharest,
2005 Ajinomoto prize
2006 Benjamin Delessert prize
2009 Foreign professor, Universitas Indonesia, Jakarta, Indonesia
Recent publications

15. Taleux N, Guigas B, Dubouchaud H, Moreno M, Weitzel JM, Goglia F, Favier R, Leverve
XM. High expression of thyroid hormone receptors and mitochondrial glycerol-3-phosphate
dehydrogenase in the liver is linked to enhanced fatty acid oxidation in Lou/C, a rat strain
resistant to obesity.
J Biol Chem 2009;284:4308-4316.
14. Ichai C, Armando G, Orban JC, Berthier F, Rami L, Samat-Long C, Grimaud D, Leverve X.
Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe
traumatic brain-injured patients.
Intensive Care Med 2009;35:471-479.
13. Cano NJ, Fouque D, Roth H, Aparicio M, Azar R, Canaud B, Chauveau P, Combe C, Laville
M, Leverve XM. Intradialytic parenteral nutrition does not improve survival in malnourished
hemodialysis patients: a 2-year multicenter, prospective, randomized study.
J Am Soc Nephrol
12. De Oliveira F., Chauvin C, Ronot X, Mousseau M, Leverve X, Fontaine E. Effects of
permeability transition inhibition and decrease in cytochrome c content on doxorubicin toxicity in
K562 cells.
Oncogene 2006;25:2646-2655.
11. Detaille D, Guigas B, Chauvin C, Batandier C, Fontaine E, Wiernsperger N, Leverve X.
Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial
permeability transition-dependent process.
Diabetes 2005;54:2179-2187.
19. Korach-Andre M, Roth H, Barnoud D, Pean M, Peronnet F, Leverve X. Glucose appearance
in the peripheral circulation and liver glucose output in men after a large 13C starch meal.
Am J
Clin Nutr 2004;80:881-886.
9. Batandier C, Leverve X, Fontaine E. Opening of the mitochondrial permeability transition pore
induces reactive oxygen species production at the level of the respiratory chain complex I.
J Biol
Chem 2004;279:17197-17204.
8. Nogueira V, Rigoulet M, Piquet MA, Devin A, Fontaine E, Leverve XM. Mitochondrial
respiratory chain adjustment to cellular energy demand.
J Biol Chem 2001;276:46104-46110.
7. Ichai C, Guignot L, El-Mir MY, Nogueira V, Guigas B, Chauvin C, Fontaine E, Mithieux G,
Leverve XM. Glucose 6-phosphate hydrolysis is activated by glucagon in a low temperature-
sensitive manner.
J Biol Chem 2001;276:28126-28133.
6. Sibille B, Filippi C, Piquet MA, Leclercq P, Fontaine E, Ronot X, Rigoulet M, Leverve X. The
mitochondrial consequences of uncoupling intact cells depend on the nature of the exogenous
Biochem J 2001;355:231-235.
5. Ichai C, El-Mir MY, Nogueira V, Piquet MA, Chauvin C, Fontaine E, Leverve XM. Exogenous
Mg- ATP induces a large inhibition of pyruvate kinase in intact rat hepatocytes. J Biol Chem
4. El-Mir MY, Nogueira V, Fontaine E, Averet N, Rigoulet M, Leverve X. Dimethylbiguanide
inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.
J Biol
Chem 2000;275:223-228.
3. Chiolero R, Tappy L, Gillet M, Revelly JP, Roth H, Cayeux C, Schneiter P, Leverve X. Effect of major hepatectomy on glucose and lactate metabolism. Ann Surg 1999;229:505-513. 2. Cano N, Catelloni F, Fontaine E, Novaretti R, di Costanzo-Dufetel J, Reynier JP, Leverve XM. Isolated rat hepatocyte metabolism is affected by chronic renal failure. Kidney Int 1995;47:1522- 1527. 1. Pison CM, Chauvin C, Fontaine E, Catelloni F, Keriel C, Paramelle B, Leverve XM. Mechanism of gluconeogenesis inhibition in rat hepatocytes isolated after in vivo hypoxia. Am J Physiol 1995;268:E965-973.


Microsoft word - 039lde2009.doc

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